Protocol · Musculoskeletal/Connective Tissue
Hypermobility Syndrome Support Protocol
Collagen and Vitamin C are the core of this stack, with 3 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Hypermobility Syndrome Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
5 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Collagen | Amount listed: 10–15 g hydrolyzed collagen peptides daily | Provides building blocks for connective tissue; may support joint stability | Not graded yet | ||
| Vitamin C | Amount listed: 500–1,000 mg daily | Essential cofactor for collagen synthesis | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Magnesium | Amount listed: 300–400 mg daily | Supports muscle function; may help with cramping and pain | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory; may help with joint pain | Not graded yet | ||
| Glucosamine/Chondroitin | Amount listed: 1,500 mg glucosamine + 1,200 mg chondroitin daily | May support cartilage health in hypermobile joints prone to wear | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Hypermobility syndrome (also called joint hypermobility syndrome or hypermobile Ehlers-Danlos syndrome) is a condition where joints easily move beyond the normal range. While some hypermobility is harmless, it can cause pain and problems for many people.
SYMPTOMS:
- Joints that bend further than normal
- Joint pain and fatigue
- Frequent joint dislocations or subluxations
- Soft, stretchy skin
- Easy bruising
- Digestive issues (sometimes)
- Fatigue and chronic pain
TYPES:
- Benign joint hypermobility (no problems)
- Hypermobility spectrum disorder
- Hypermobile EDS (hEDS) - most common EDS type
KEY MANAGEMENT:
- Physical therapy is cornerstone (strengthen muscles to support joints)
- Low-impact exercise (swimming, Pilates)
- Joint protection techniques
- Pain management
- Pacing activities
IMPORTANT:
- Many people with hypermobility do fine with proper management
- Focus on strengthening, not stretching
- Avoid overextending joints
Collagen and vitamin C* support connective tissue.
Physical therapy* is most important treatment.
Strengthening exercises* protect joints.
Expected timeline: Management is ongoing. Supplements may support connective tissue health with consistent use over months.