Protocol · Gastrointestinal/Autoimmune
Crohn's Disease Supportive Care Protocol
Vitamin D and Omega-3 Fatty Acids are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Crohn's Disease Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (higher doses may be needed based on levels) | Deficiency very common; supports immune modulation and bone health | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA+DHA daily | Anti-inflammatory; may help maintain remission | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Probiotics | Amount listed: 10–50 billion CFU daily (specific strains like Saccharomyces boulardii) | May help with gut microbiome balance; evidence mixed for Crohn's specifically | Not graded yet | ||
| Iron | Amount listed: If deficient: 27–65 mg elemental iron daily; IV iron if oral not tolerated | Anemia common due to blood loss and malabsorption | Not graded yet | ||
| Vitamin B12 | Amount listed: 1,000 mcg daily or as injections if severe deficiency | Deficiency common with ileal disease or resection | Not graded yet | ||
| Zinc | Amount listed: 15–30 mg daily | Deficiency common; supports immune function and wound healing | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Crohn's Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Crohn's disease is a type of inflammatory bowel disease (IBD) that can affect any part of the digestive tract, most commonly the end of the small intestine (ileum) and beginning of the colon.
KEY FEATURES:
- Chronic, relapsing-remitting course
- Can affect any part of GI tract (mouth to anus)
- Inflammation is transmural (affects full bowel wall)
- May cause strictures, fistulas, abscesses
SYMPTOMS:
- Abdominal pain and cramping
- Diarrhea (may be bloody)
- Fatigue
- Weight loss
- Reduced appetite
- Fever
- Mouth sores
- Perianal disease
NUTRITIONAL DEFICIENCIES (common):
- Vitamin D
- Vitamin B12 (especially with ileal disease)
- Iron
- Zinc
- Folate
- Calcium
MEDICAL TREATMENTS:
- Aminosalicylates (mild disease)
- Corticosteroids (flares)
- Immunomodulators (azathioprine, methotrexate)
- Biologics (anti-TNF, vedolizumab, ustekinumab)
- Surgery (for complications)
NUTRITION:
- No single diet works for everyone
- Identify and avoid personal trigger foods
- Adequate calories and protein
- Correct deficiencies
- Low-residue diet during flares
Vitamin D* deficiency is very common - check and correct.
B12 monitoring* especially with ileal involvement.
Work with GI specialist* for medical management.
Expected timeline: Disease requires lifelong management. Supplements address deficiencies and may provide modest supportive benefit.