Protocol · Autoimmune & Inflammatory
Autoimmune Disease General Support Protocol
Vitamin D and Omega-3 Fatty Acids are the core of this stack, with 6 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Autoimmune Disease General Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
8 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Vitamin D | Amount listed: 2,000–5,000 IU daily (target 40–60 ng/mL; higher may be needed) | Immunomodulatory effects; deficiency strongly associated with autoimmune disease risk and severity | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 3–4 g EPA+DHA daily | Anti-inflammatory; modulate immune response; may reduce disease activity across many autoimmune conditions | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Curcumin | Amount listed: 500–1,000 mg enhanced-absorption curcumin 2–3 times daily | Potent anti-inflammatory via NF-kB inhibition; may help modulate autoimmune inflammation | Not graded yet | ||
| Probiotics | Amount listed: 20–50 billion CFU multi-strain daily | Support gut health and immune regulation; gut-immune connection important in autoimmunity | Not graded yet | ||
| Glutathione/NAC | Amount listed: 600–1,200 mg NAC twice daily (or liposomal glutathione 500–1,000 mg) | Master antioxidant; supports detoxification; may help reduce oxidative stress in autoimmunity | Not graded yet | ||
| Selenium | Amount listed: 100–200 mcg daily (don't exceed 400 mcg) | Supports thyroid function and immune regulation; deficiency linked to autoimmune thyroid disease | Not graded yet | ||
| Vitamin B12 and Folate | Amount listed: B12 1,000 mcg, Folate 400–800 mcg daily (methylated forms) | Support methylation and immune function; deficiency common in some autoimmune conditions | Not graded yet | ||
| Magnesium | Amount listed: 300–400 mg daily | Supports immune function; deficiency can worsen inflammation | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Autoimmune Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues. There are over 80 different autoimmune conditions, including rheumatoid arthritis, lupus, multiple sclerosis, Hashimoto's thyroiditis, type 1 diabetes, inflammatory bowel disease, and many others. These conditions share common features of inflammation and immune dysregulation, even though they affect different organs. While each condition has specific treatments, there are general supportive strategies that may benefit many autoimmune conditions.
CRITICAL: Autoimmune diseases require proper medical diagnosis and treatment. Many conditions need disease-modifying medications to prevent organ damage. These include DMARDs, biologics, or other immunosuppressants depending on the specific condition. Don't rely on supplements alone - they provide supportive care but don't replace essential medications. Always work with your rheumatologist, immunologist, or specialist for your specific condition.
Vitamin D* has powerful immunomodulatory effects and deficiency is strongly linked to autoimmune disease. Studies show adequate vitamin D levels are associated with better outcomes across many autoimmune conditions. Higher levels (40-60 ng/mL) may be more beneficial than just avoiding deficiency.
Omega-3 Fatty Acids* reduce inflammation through multiple pathways. They have been shown to benefit many autoimmune conditions including rheumatoid arthritis, lupus, inflammatory bowel disease, and others.
Curcumin* is a potent anti-inflammatory that works through NF-kB inhibition. It may help reduce inflammation across various autoimmune conditions.
Probiotics* support gut health, which is increasingly recognized as important in autoimmunity. The gut-immune connection means a healthy microbiome may help regulate immune responses.
NAC/Glutathione* supports the body's antioxidant defenses. Oxidative stress is elevated in many autoimmune conditions.
Selenium* is particularly important for thyroid autoimmune conditions but also supports general immune regulation.
B Vitamins* support methylation and immune function. Deficiencies are common in certain autoimmune conditions.
Magnesium* supports immune function and helps reduce inflammation.
Expected timeline: Vitamin D optimization takes 2-3 months to reach target levels. Anti-inflammatory effects from omega-3 and curcumin may be noticed within 4-8 weeks. Probiotic effects on gut-immune axis take 4-12 weeks. Autoimmune disease management is typically lifelong.