Condition
Venous Thromboembolism (Blood Clotting)
Venous thromboembolism is a blood clot that forms in a deep vein, usually in the leg, and can break loose and travel to the lungs, where it blocks blood flow. Omega-3 fatty acids and vitamin D are the supplements people look at most, but little research on them for this condition has been reviewed here so far. Their mild effects on platelets and clotting are plausible on paper, yet no trial findings can be reported, so the evidence is too thin to say whether they matter.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 26,779
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Thromboembolism Risk | Changes; see studies | 1 study | 26,779 people | |||
Studies that measured thromboembolism risk | ||||||
The Venous Thromboembolism (DVT/PE) Prevention Support protocol
2 primary supplements · 6 supporting supplements
- Omega-3 Fatty Acids1–2 g EPA+DHA daily (CAUTION: discuss with doctor if on anticoagulants)
- Vitamin D2,000–4,000 IU daily (monitor levels)
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Venous Thromboembolism (Blood Clotting). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
63 studies from PubMed
- The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis.
- Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia
- Evaluating the effects of vitamin D and vitamin E supplement on premenstrual syndrome: A randomized, double-blind, controlled trial
- Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers
- Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
- Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
- Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
- Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
- Effects of gamma-tocopherol supplementation on thrombotic risk factors
- Aspirin prevents stroke but not MI in women; vitamin E has no effect on CV disease or cancer
- Effects of vitamin E on stroke: a systematic review with meta-analysis and trial sequential analysis.
- Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials.
- The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients
- The relationship between dose of vitamin E and suppression of oxidative stress in humans
- Effects of vitamin E on lipid peroxidation in healthy persons
- Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E
- Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults
- Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults
- Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus
- Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
- Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
- Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial
- Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
- Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial
- Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
- Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study
- Long-term (>=2 yr) efficacy of vitamin E for non-alcoholic steatohepatitis
- Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
- Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes
- Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes
- Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial
- Increased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects of alpha-tocopherol supplementation
- Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
- Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study
- Study on the effect of megavitamin E supplementation in man
- Megavitamin E supplementation in man
- Effects of elevated d-alpha(RRR)-tocopherol dosage in man
- A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea
- A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea
- Evaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrhea
- Effect of vitamin E therapy on sexual functions of uremic patients in hemodialysis
- The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates
- alpha-Tocopherol supplementation in racing cyclists during extreme endurance training
- Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise
- Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study
- Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial
- Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study
- Vitamin E supplementation and cataract: randomized controlled trial
- Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial
- Effects of tocotrienol supplementation on hair growth in human volunteers
- Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.
- Vitamin E and donepezil for the treatment of mild cognitive impairment
- Vitamin E for Alzheimer's dementia and mild cognitive impairment.
- Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial
- A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
- A randomized trial of vitamin E supplementation and cognitive function in women
- Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery
- The effects of topical vitamin E on the cosmetic appearance of scars
- Therapeutic effects of vitamin E on cyclic mastalgia
- Rectal administration of d-alpha tocopherol for active ulcerative colitis: a preliminary report
- Vitamin E supplementation in people with cystic fibrosis.
- Vitamin E for people with non-alcoholic fatty liver disease.
- Renal protective effects of vitamin E for drug-induced kidney injury: a meta-analysis.