Condition
Subfertility
Subfertility means conceiving takes longer than expected, arising from ovulation problems, blocked tubes, endometriosis, low sperm count or motility, or sometimes no identified cause. The evidence is strongest for folate and myo-inositol, the latter especially in PCOS-related infertility, while kisspeptin-54 injections stimulated luteinizing hormone release in healthy women and those with hypothalamic amenorrhea. That kisspeptin work measured hormone release rather than pregnancies, and in one study repeated dosing made the response fade.
Sources: PMID 19820030; PMID 38265397
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 3
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| LH Secretion Kisspeptin-54 potently stimulates LH release in healthy women and those with hypothalamic amenorrhea, with effects similar to or exceeding exogenous GnRH. | Improves (the measure goes up) | Large effect | 13 studies | |||
| FSH Secretion Acute kisspeptin administration increases FSH secretion as part of the coordinated gonadotropin response through the hypothalamic-pituitary axis. | Improves (the measure goes up) | Moderate effect | 13 studies | |||
| Reproductive Hormone Recovery (Hypothalamic Amenorrhea) Twice-weekly kisspeptin-54 administration for 8 weeks stimulated reproductive hormone release in women with hypothalamic amenorrhea, though chronic administration shows tachyphylaxis. | Improves (the measure goes up) | Moderate effect | 12 studies | |||
Studies that measured reproductive hormone recovery (hypothalamic amenorrhea) | ||||||
Key findings
- LH SecretionImproves (the measure goes up)
- FSH SecretionImproves (the measure goes up)
- Reproductive Hormone Recovery (Hypothalamic Amenorrhea)Improves (the measure goes up)
The Subfertility Support (Male and Female) protocol
2 primary supplements · 8 supporting supplements
- Folate/Folic Acid400–800 mcg methylfolate daily (women); 400 mcg daily (men)
- Coenzyme Q10200–600 mg daily
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Studies cited
29 studies from PubMed
- Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment
- Kisspeptin and its Current Clinical Status-A Systematic Review.
- Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction
- Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.
- Clinical Potential of Kisspeptin in Reproductive Health
- MINI REVIEW: Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals.
- Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders
- Role of Kisspeptin in Regulation of Reproductive and Immune Reactions.
- Kisspeptin Influence on Polycystic Ovary Syndrome-a Mini Review.
- The role of kisspeptin system in cancer biology.
- KISS1/KISS1R and Breast Cancer: Metastasis Promoter.
- Kisspeptin/Kisspeptin Receptor System in the Ovary
- The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis.
- A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.
- Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy
- Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization
- The kisspeptin-GnRH pathway in human reproductive health and disease
- Kisspeptin-54 levels are increased in patients with colorectal cancer.
- Plasma Kisspeptin-54 levels in gastric cancer patients.
- Kisspeptin and fertility.
- The role of kisspeptin/GPR54 in the reproductive system.
- Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea
- Kisspeptin: a critical regulator of puberty and reproductive function.
- Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis
- Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge.
- Kisspeptin: a novel role in the regulation of reproductive function.
- Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women.
- The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans
- Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males