Condition
Pancreatitis
Pancreatitis is inflammation of the pancreas, the organ that makes digestive enzymes and insulin; in acute cases, those enzymes switch on inside the gland and digest it. The evidence is strongest for pancreatic enzymes and vitamin D, which address poor digestion and low fat-soluble vitamins, while secretin testing assessed pancreatic function with roughly 79 to 92 percent accuracy. Curcumin raised antioxidant enzymes in only 20 people, so that finding is early.
Sources: PMID 22194487; PMID 24222963
- Supplements studied
- 1
- Medicines and peptides
- 2
- Graded outcomes
- 5
- Trials
- 1
- People studied
- 20
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Moderate Increase | Improves (the measure goes up) | Moderate effect | 20 people | |||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 6 studies | 20 people | |||
Studies that measured oxidative stress biomarkers
| ||||||
| Pancreatitis Symptoms | Improves (the measure goes down) | 1 study | 20 people | |||
Studies that measured pancreatitis symptoms | ||||||
Prescription medicines and peptides studied, for context
Secretin (ChiRhoStim)
- Pancreatic Function Assessment: improves
- Early Pancreatitis Detection: improves
- MRCP Enhancement: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pancreatic Function Assessment Endoscopic secretin test: peak bicarbonate <80 mEq/L indicates exocrine insufficiency. Normal response: mean peak 100 mEq/L. 79-92% diagnostic accuracy. | Improves (the measure goes up) | Large effect | 14 studies | |||
| Early Pancreatitis Detection S-MRCP detects early-stage reversible chronic pancreatitis. Signal intensity ratio <1.7 has 92% sensitivity, 75% specificity for early disease. Identifies subtle ductal abnormalities. | Improves (the measure goes up) | Large effect | 14 studies | |||
| MRCP Enhancement Secretin-enhanced MRCP increases chronic pancreatitis detection sensitivity from 77% to 89%. Improves ductal visualization 4-fold. NPV increases from 84% to 98%. | Improves (the measure goes up) | Large effect | 12 studies |
Sincalide (Kinevac)
- Pancreatic Enzyme Secretion: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pancreatic Enzyme Secretion Combined with secretin for pancreatic function testing. Stimulates enzyme (lipase, amylase) secretion into duodenum. Used for duodenal aspirate analysis in chronic pancreatitis evaluation. | Improves (the measure goes up) | Large effect | 6 studies |
Key findings
- Anti-Oxidant Enzyme ProfileImproves (the measure goes up)
The Pancreatitis Recovery & Chronic Management Support protocol
2 primary supplements · 7 supporting supplements
- Pancreatic EnzymesPrescription PERT: 40,000–50,000 lipase units with meals, 20,000–25,000 with snacks
- Vitamin D2,000–4,000 IU daily (often higher doses needed; monitor levels)
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Pancreatitis. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
100 studies from PubMed
- Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
- Gastrointestinal cholecystokinin signaling pathway drugs modulate osteogenic/cementogenic differentiation of human periodontal ligament stem cells.
- The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.
- The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis.
- Ojeok-san enhances platinum sensitivity in ovarian cancer by regulating adipocyte paracrine IGF1 secretion.
- HDAC1-Mediated Downregulation of NEU1 Exacerbates the Aggressiveness of Cervical Cancer.
- All you need to know about gastrinoma today: Gastrinoma and Zollinger-Ellison syndrome: A thorough update
- Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model.
- Defining Biliary Hyperkinesia and the Role of Cholecystectomy
- Secretin Receptor as a Target in Gastrointestinal Cancer: Expression Analysis and Ligand Development.
- C1QTNF6 Targeted by MiR-184 Regulates the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells.
- Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight.
- Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
- Cholescintigraphy may have a role in selecting patients with biliary dyskinesia for cholecystectomy: a systematic review
- Utilizing the Cholecystagogue, Ensure Plus, Results in Similar Hepatobiliary Scintigraphy Study Results and Patient Outcomes Status Post Cholecystectomy, in Comparison With Sincalide.
- Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues.
- Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study
- Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled Trial
- The clinical value of secretin-enhanced MRCP in the functional and morphological assessment of pancreatic diseases
- Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
- Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
- The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis
- Secretin-enhanced MR Imaging of the Pancreas
- Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers.
- A Phase II Trial of Human Secretin Infusion for Refractory Type B Pain in Chronic Pancreatitis: Erratum.
- Diagnostic Performance of Contrast-Enhanced MRI With Secretin-Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology
- Endoscopic Pancreatic Function Test using Combined Secretin and Cholecystokinin Stimulation for the Evaluation of Chronic Pancreatitis
- Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption.
- Pain provocation and low gallbladder ejection fraction with CCK cholescintigraphy are not predictive of chronic acalculous gallbladder disease symptom relief after cholecystectomy
- Classification schema of symptomatic enterogastric reflux utilizing sincalide augmentation on hepatobiliary scintigraphy.
- Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP
- A phase II trial of human secretin infusion for refractory type B pain in chronic pancreatitis.
- Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine function
- Optimum utilization of cholecystokinin cholescintigraphy (CCK-HIDA) in clinical practice: an evidence based review
- Dicyclomine: cause of abnormally decreased gall bladder ejection with sincalide-stimulated hepatobiliary scintigraphy.
- Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects
- Extragastrointestinal functions and transcriptional regulation of secretin and secretin receptors.
- Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects
- Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen
- Diagnostic efficacy of the secretin stimulation test for the Zollinger-Ellison syndrome: an intra-individual comparison using different dosages in patients and controls
- Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization.
- Sincalide-Stimulated Cholescintigraphy: A Multicenter Investigation to Determine Optimal Infusion Methodology and Gallbladder Ejection Fraction Normal Values
- Extended application of 99mTc-mebrofenin cholescintigraphy with cholecystokinin in the evaluation of abdominal pain of hepatobiliary and gastrointestinal origin.
- Diagnostic yield of ERCP and secretin-enhanced MRCP and EUS in patients with acute recurrent pancreatitis of unknown aetiology
- Gateways to clinical trials.
- Diagnosis of BD relied in great measure on gallbladder ejection fraction (GBEF) after sincalide stimulation on hepatobiliary scintigraphy.
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
- Biliary dyskinesia
- Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatography
- Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal
- Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials.
- Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controls
- Expression and functions of the duodenal peptide secretin and its receptor in human lung.
- Secretin as a treatment for autism: a review of the evidence.
- Laparoscopic cholecystectomy for biliary dyskinesia: correlation of preoperative cholecystokinin cholescintigraphy results with postoperative outcome
- Systematic review and meta-analysis: does gall-bladder ejection fraction on cholecystokinin cholescintigraphy predict outcome after cholecystectomy in suspected functional biliary pain?
- Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo.
- Effect of atropine and sincalide on the intestinal uptake of F-18 fluorodeoxyglucose.
- Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.
- Cholecystokinin octapeptide (CCK-8): a negative feedback control mechanism for opioid analgesia.
- Hemobilia presenting as intermittent gastrointestinal hemorrhage with sincalide confirmation. A case report.
- Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia
- Preparation of radioiodinated secretin for radioimmunoassay.
- Secretin as a potential mediator of antiulcer actions of mucosal protective agents.
- Cholecystokinin enhanced hepatobiliary scanning with ejection fraction calculation as an indicator of disease of the gallbladder
- Kinevac (sincalide for injection)/Squibb Diagnostics
- Ultrastructural identification of human secretin cells by the immunogold technique. Their costorage of chromogranin A and serotonin.
- Processing of prosecretin: isolation of a secretin precursor from porcine intestine.
- Sincalide-augmented quantitative hepatobiliary scintigraphy (QHBS): definition of normal parameters and preliminary relationship between QHBS and sphincter of Oddi (SO) manometry in patients suspected of having SO dysfunction.
- Secretin provocation test in the diagnosis of Zollinger-Ellison syndrome
- Pharmacology, molecular identification and functional characteristics of vasoactive intestinal peptide receptors in human breast cancer cells.
- Dopamine neuronal tracts in schizophrenia: their pharmacology and in vivo glucose metabolism.
- Cholecystokinin and pain.
- [Secretin and peptic ulcer].
- Practical hepatobiliary imaging using pretreatment with sincalide in 139 hepatobiliary studies.
- Secretin-like immunoreactivity and biological activity in the antral mucosa.
- [Gastrointestinal hormones and related neuropeptides. II. The secretin group: secretin].
- Radioimmunoassay of secretin. A critical review and current status.
- Radioimmunoassay of secretin.
- Immunoreactive secretin and exocrine pancreatic secretion.
- Radioimmunoassay measurement of secretin half-life in man.
- Immunological aspects of secretin, substance P, and VIP.
- [Radioimmunoassay for secretin].
- Radioimmunoassay of secretin in plasma.
- [Clinical use of secretin (literature review and personal data)].
- Efficacy of Curcuma longa in relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta-analysis of clinical trials.
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
- Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
- Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
- Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial
- Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial
- Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
- Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis
- The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial
- A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OA
- Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis
- Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
- Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis.