Zollinger-Ellison Syndrome
A rare condition caused by gastrin-secreting tumors (gastrinomas) leading to severe peptic ulcer disease and gastric acid hypersecretion. Diagnosis often requires provocative testing with secretin.
Quick Answer
What it is
A rare condition caused by gastrin-secreting tumors (gastrinomas) leading to severe peptic ulcer disease and gastric acid hypersecretion. Diagnosis often requires provocative testing with secretin.
Key findings
- Grade A: Gastrinoma Detection (Secretin (ChiRhoStim))
- Grade A: Diagnostic Accuracy ZES (Secretin (ChiRhoStim))
Safety
- Must discontinue PPIs to avoid false positives.
ℹ️ Quick Facts
Quick Facts: Zollinger-Ellison Syndrome
- Supplements Studied:1
1 supps · 2 outcomes
Detailed Outcomes
A
Gastrinoma Detection
Secretin stimulation test: gastrin rise ≥120 pg/mL diagnostic for gastrinoma. Sensitivity 92-96%, specificity 100% in properly controlled studies. Preferred provocative test for ZES.
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A
Diagnostic Accuracy ZES
Peak gastrin response distinguishes ZES from other hypergastrinemic states. Must discontinue PPIs to avoid false positives. Negative predictive value >95%.
large↑Improves