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Dr. Grey AI

Peptide

Secretin (ChiRhoStim)

Secretin is a 27-amino acid peptide hormone. FDA-approved in 2004 for diagnostic use. Stimulates pancreatic bicarbonate secretion for exocrine function testing. Secretin stimulation test has 92-96% sensitivity for gastrinoma/ZES diagnosis. Used in secretin-enhanced MRCP with 89% sensitivity for chronic pancreatitis detection. Also facilitates ERCP cannulation.

Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.

Best evidence
Grade A
Conditions studied
2
Outcomes
12
Graded outcomes
5232

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

2 conditions, plus general outcomes

Pancreatitis

Pancreatitis: outcomes studied for Secretin (ChiRhoStim)
GradeOutcomeEffectSizeStudiesPeopleStudies list
Pancreatic Function Assessment

Endoscopic secretin test: peak bicarbonate <80 mEq/L indicates exocrine insufficiency. Normal response: mean peak 100 mEq/L. 79-92% diagnostic accuracy.

Improves (the measure goes up)Large effect14 studies

Studies that measured pancreatic function assessment

and 4 more in the citations list

Early Pancreatitis Detection

S-MRCP detects early-stage reversible chronic pancreatitis. Signal intensity ratio <1.7 has 92% sensitivity, 75% specificity for early disease. Identifies subtle ductal abnormalities.

Improves (the measure goes up)Large effect14 studies

Studies that measured early pancreatitis detection

and 4 more in the citations list

MRCP Enhancement

Secretin-enhanced MRCP increases chronic pancreatitis detection sensitivity from 77% to 89%. Improves ductal visualization 4-fold. NPV increases from 84% to 98%.

Improves (the measure goes up)Large effect12 studies

Studies that measured mrcp enhancement

and 2 more in the citations list

Zollinger-Ellison Syndrome

Zollinger-Ellison Syndrome: outcomes studied for Secretin (ChiRhoStim)
GradeOutcomeEffectSizeStudiesPeopleStudies list
Gastrinoma Detection

Secretin stimulation test: gastrin rise ≥120 pg/mL diagnostic for gastrinoma. Sensitivity 92-96%, specificity 100% in properly controlled studies. Preferred provocative test for ZES.

Improves (the measure goes up)Large effect9 studies

Studies that measured gastrinoma detection

Diagnostic Accuracy ZES

Peak gastrin response distinguishes ZES from other hypergastrinemic states. Must discontinue PPIs to avoid false positives. Negative predictive value >95%.

Improves (the measure goes up)Large effect9 studies

Studies that measured diagnostic accuracy zes

General

General: outcomes studied for Secretin (ChiRhoStim)
GradeOutcomeEffectSizeStudiesPeopleStudies list
Immune Function

10 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.

Improves (the measure goes up)Moderate effect14 studies

Studies that measured immune function

and 4 more in the citations list

GI Protection

9 human trials support this finding. Human clinical trial data available.

Improves (the measure goes up)Moderate effect13 studies

Studies that measured gi protection

and 3 more in the citations list

Body Weight

4 preclinical studies support this finding. Primarily preclinical evidence.

Improves (the measure goes down)Small effect8 studies

Studies that measured body weight

Anti-Cancer Activity

3 human trials support this finding. Human clinical trial data available.

Improves (the measure goes up)Small effect7 studies

Studies that measured anti-cancer activity

Lipid Profile

3 human trials support this finding. Human clinical trial data available.

Improves (the measure goes down)Small effect7 studies

Studies that measured lipid profile

Pulmonary Function

2 human trials support this finding. Human clinical trial data available.

Improves (the measure goes up)Small effect6 studies
Pain

2 human trials support this finding. Human clinical trial data available.

Improves (the measure goes down)Small effect6 studies

Key findings

  • Pancreatic Function AssessmentPancreatitisImproves (the measure goes up)
  • Early Pancreatitis DetectionPancreatitisImproves (the measure goes up)
  • MRCP EnhancementPancreatitisImproves (the measure goes up)

Safety notes in the studies

  • Must discontinue PPIs to avoid false positives.

Studies cited

44 studies from PubMed

  1. All you need to know about gastrinoma today: Gastrinoma and Zollinger-Ellison syndrome: A thorough updateBiochim Biophys Acta Rev Cancer, 2023 · PMID 37042078
  2. Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model.Molecular metabolism, 2023 · PMID 37390979
  3. Secretin Receptor as a Target in Gastrointestinal Cancer: Expression Analysis and Ligand Development.Biomedicines, 2022 · PMID 35327338
  4. Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight.Endocrinology, 2021 · PMID 34089599
  5. Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?Frontiers in endocrinology, 2021 · PMID 34671320
  6. The clinical value of secretin-enhanced MRCP in the functional and morphological assessment of pancreatic diseasesAbdom Radiol, 2018 · PMID 29206061
  7. The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute PancreatitisAm J Roentgenol, 2016 · PMID 27824485
  8. Secretin-enhanced MR Imaging of the PancreasMagn Reson Imaging Clin N Am, 2016 · PMID 26989929
  9. Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2016 · PMID 26725182
  10. A Phase II Trial of Human Secretin Infusion for Refractory Type B Pain in Chronic Pancreatitis: Erratum.Pancreas, 2016 · PMID 27077722
  11. Diagnostic Performance of Contrast-Enhanced MRI With Secretin-Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With HistopathologyAJR Am J Roentgenol, 2015 · PMID 26372506
  12. Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014 · PMID 24769669
  13. Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCPWorld J Gastroenterol, 2013 · PMID 24222963
  14. A phase II trial of human secretin infusion for refractory type B pain in chronic pancreatitis.Pancreas, 2013 · PMID 23548879
  15. Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine functionAbdom Imaging, 2012 · PMID 22194487
  16. Extragastrointestinal functions and transcriptional regulation of secretin and secretin receptors.Annals of the New York Academy of Sciences, 2011 · PMID 21388401
  17. Diagnostic efficacy of the secretin stimulation test for the Zollinger-Ellison syndrome: an intra-individual comparison using different dosages in patients and controlsRegul Pept, 2010 · PMID 20299818
  18. Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization.Regulatory peptides, 2010 · PMID 20541569
  19. Diagnostic yield of ERCP and secretin-enhanced MRCP and EUS in patients with acute recurrent pancreatitis of unknown aetiologyGastrointest Endosc, 2009 · PMID 19278909
  20. Gateways to clinical trials.Methods and findings in experimental and clinical pharmacology, 2009 · PMID 19907722
  21. Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatographyPancreas, 2007 · PMID 17238039
  22. Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials.Research in developmental disabilities, 2005 · PMID 15590241
  23. Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controlsPancreas, 2004 · PMID 15017660
  24. Expression and functions of the duodenal peptide secretin and its receptor in human lung.American journal of respiratory cell and molecular biology, 2004 · PMID 15191914
  25. Secretin as a treatment for autism: a review of the evidence.Journal of autism and developmental disorders, 2004 · PMID 15628608
  26. Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo.Peptides, 2002 · PMID 12182944
  27. Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.The Journal of pharmacology and experimental therapeutics, 1996 · PMID 8930157
  28. Preparation of radioiodinated secretin for radioimmunoassay.Annals of nuclear medicine, 1991 · PMID 1764343
  29. Secretin as a potential mediator of antiulcer actions of mucosal protective agents.Journal of clinical gastroenterology, 1991 · PMID 1940202
  30. Ultrastructural identification of human secretin cells by the immunogold technique. Their costorage of chromogranin A and serotonin.Histochemistry, 1990 · PMID 1972699
  31. Processing of prosecretin: isolation of a secretin precursor from porcine intestine.Proceedings of the National Academy of Sciences of the United States of America, 1990 · PMID 2395872
  32. Secretin provocation test in the diagnosis of Zollinger-Ellison syndromeAnn Intern Med, 1989 · PMID 1992623
  33. Pharmacology, molecular identification and functional characteristics of vasoactive intestinal peptide receptors in human breast cancer cells.Cancer research, 1988 · PMID 2842044
  34. [Secretin and peptic ulcer].Terapevticheskii arkhiv, 1985 · PMID 4002139
  35. Secretin-like immunoreactivity and biological activity in the antral mucosa.Endocrinology, 1983 · PMID 6347663
  36. [Gastrointestinal hormones and related neuropeptides. II. The secretin group: secretin].Postepy higieny i medycyny doswiadczalnej, 1983 · PMID 6387677
  37. Radioimmunoassay of secretin. A critical review and current status.Digestive diseases and sciences, 1980 · PMID 6104568
  38. Radioimmunoassay of secretin.Gastroenterology, 1978 · PMID 648833
  39. Immunoreactive secretin and exocrine pancreatic secretion.Gastroenterology, 1978 · PMID 700332
  40. Radioimmunoassay measurement of secretin half-life in man.Gastroenterology, 1977 · PMID 830238
  41. Immunological aspects of secretin, substance P, and VIP.Gastroenterology, 1977 · PMID 838240
  42. [Radioimmunoassay for secretin].Schweizerische medizinische Wochenschrift, 1977 · PMID 854726
  43. Radioimmunoassay of secretin in plasma.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1976 · PMID 1086282
  44. [Clinical use of secretin (literature review and personal data)].Terapevticheskii arkhiv, 1972 · PMID 4573054