Glaucoma

Glaucoma is a group of eye conditions, the common feature of which is characteristic damage of the optic nerve which transmits light signals to the brain. Left untreated, glaucoma can cause irreversible vision loss. Currently, the only established modifiable risk factor for glaucoma is elevated pressure inside the eye.

Quick Answer

What it is

Glaucoma is a group of eye conditions, the common feature of which is characteristic damage of the optic nerve which transmits light signals to the brain. Left untreated, glaucoma can cause irreversible vision loss.

Key findings

  • Grade C: Blood Pressure (Cannabis)
  • Grade C: Visual acuity (VA) (CDP-Choline)
  • Grade D: Intraocular Pressure (CDP-Choline)

Safety

  • Currently, the only established modifiable risk factor for glaucoma is elevated pressure inside the eye.
ℹ️ Quick Facts

Quick Facts: Glaucoma

  • Supplements Studied:4
  • Research Trials:4
  • Total Participants:168
  • Top Supplement:CDP-Choline (C)
4 trials
168 ppts
4 supps · 8 outcomes

Evidence-Based Protocol

Supplement stack ranked by research quality

Limited Evidence

Primary Stack (Tier 1)

500-1000mg daily

Neuroprotective effects on retinal ganglion cells; may slow visual field deterioration

10 studies | 600 participants
2-3g EPA+DHA daily

May improve ocular blood flow and have neuroprotective effects; support retinal health

8 studies | 500 participants

Supporting Stack (Tier 2)

120-240mg standardized extract daily

May improve ocular blood flow; neuroprotective and antioxidant effects

10 studies | 500 participants
500-1000mg daily

Antioxidant; may transiently reduce intraocular pressure; supports eye health

6 studies | 300 participants
100-200mg daily

Mitochondrial support; may protect retinal ganglion cells from oxidative damage

6 studies | 300 participants
300-600mg daily

Antioxidant with potential neuroprotective effects on retinal ganglion cells

5 studies | 200 participants
160-320mg standardized extract daily

Anthocyanins support retinal microcirculation and may protect against oxidative stress

5 studies | 250 participants
300-400mg daily

May improve ocular blood flow through vasodilation; supports nerve function

5 studies | 200 participants
B12 1000mcg, Folate 400-800mcg daily

May support optic nerve health; elevated homocysteine associated with glaucoma

5 studies | 300 participants

How It Works

Glaucoma is a group of eye conditions that damage the optic nerve, usually due to elevated intraocular pressure (IOP). It's a leading cause of irreversible blindness worldwide. The most common types are open-angle glaucoma (develops slowly, often without symptoms until significant vision loss) and angle-closure glaucoma (can be acute emergency). Vision loss from glaucoma cannot be recovered - the goal is preventing further damage.

CRITICAL: Glaucoma requires ongoing medical management. The primary treatment is lowering intraocular pressure through eye drops, laser treatment, or surgery. Regular eye exams with pressure checks and visual field testing are essential to monitor progression. Never stop or change your glaucoma medications without consulting your ophthalmologist. These supplements may provide additional support for optic nerve health but DO NOT replace IOP-lowering treatment. Acute angle-closure glaucoma is an emergency requiring immediate treatment.

* Citicoline (CDP-Choline) has the strongest evidence among glaucoma supplements. It has neuroprotective effects on retinal ganglion cells - the cells that die in glaucoma. Clinical trials show it may help slow visual field deterioration when added to standard IOP-lowering treatment.

* Omega-3 Fatty Acids may improve ocular blood flow and have anti-inflammatory and neuroprotective effects that support retinal health.

* Ginkgo Biloba may improve blood flow to the optic nerve and has antioxidant and neuroprotective properties. Some studies show benefit for visual field progression.

* Vitamin C is an antioxidant that may have a modest IOP-lowering effect, though this is likely not clinically significant for glaucoma treatment.

* Coenzyme Q10 supports mitochondrial function in retinal ganglion cells and may protect against oxidative damage.

* Alpha-Lipoic Acid is an antioxidant that may provide neuroprotection to the optic nerve.

* Bilberry Extract contains anthocyanins that support retinal microcirculation and eye health.

* Magnesium may improve blood flow to the optic nerve through vasodilation.

* B Vitamins - elevated homocysteine is associated with glaucoma risk; B12 and folate help lower homocysteine.

Expected timeline: Citicoline effects on visual function may be seen over months of consistent use. Glaucoma management is lifelong, with the focus on preventing further vision loss.

Generated from peer-reviewed researchSchema v2.0

Detailed Outcomes

|
C
Blood Pressure
Mixed effect
1 study
?
Heart Rate
1 study
Improves
?
Intraocular Pressure
1 study
Improves
C
Blood Pressure
Small Improvement
1 study
smallImproves
?
Intraocular Pressure
1 study
Improves
C
Visual acuity (VA)
Small Improvement
1 study
smallImproves
D
Intraocular Pressure
No effect on intraocular pressure
1 study
none
?
Ocular Blood Flow
1 study
Improves

Related Conditions

Cognitive Improvement

4 shared supplements · 324 outcomes

Cognitive improvement refers to an increase in performance on tasks of mental abilities including learning, thinking, memory, problem solving, logical reasoning, decision making, and attention.

Weight Loss & Maintenance

3 shared supplements · 433 outcomes

This goal refers to people with a BMI >25 attempting to reach/maintain their ideal weight. While interventions that work for people with a BMI >25 may also work for people with a lower BMI, the context is often sufficiently different that this isn't assured.

Type 2 Diabetes

3 shared supplements · 868 outcomes

Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.

Mood Improvement

3 shared supplements · 159 outcomes

Mood improvement refers to a beneficial change in one’s temporary mental or emotional state which can include improvements in feelings of anxiety, anger, sadness, relief, positivity, optimism, loneliness, insecurity, happiness, excitement, curiosity, and calmness.

3 shared supplements · outcomes

Eye Health

3 shared supplements · 35 outcomes

Eye health refers to the proper function of all aspects of the eye that contribute to vision and tear production including the cornea, pupil, lens, retina, optic nerves, and tear glands. Eye health is important to prevent eye diseases like macular degeneration and glaucoma.

Sleep Health

2 shared supplements · 84 outcomes

Sleep health encompasses a holistic view of sleep that includes sleep regularity, sleep timing, sleep quality, sleep duration, and satisfaction with one’s sleep.

Skin Health

2 shared supplements · 110 outcomes

Skin health refers to the integrity of skin function. Healthy skin maintains a barrier between the external environment and the inside of the body, and is characterized as smooth, moisturized, clear of blemishes, and radiant.