Pedalium murex

Pedalium murex is an Ayurvedic herb used interchangeably with Tribulus terrestris in Gokshura formulations due to similar-looking fruits. VERY LIMITED EVIDENCE. One rat study suggests testosterone increase and aphrodisiac effects - more promising than Tribulus for testosterone but only animal data. Bioactive compounds not well characterized. NO human studies. Used traditionally for urinary disorders and male vitality. Cannot recommend over better-studied alternatives.

Quick Answer

What it is

Pedalium murex is an Ayurvedic herb used interchangeably with Tribulus terrestris in Gokshura formulations due to similar-looking fruits. VERY LIMITED EVIDENCE.

Key findings

Grade C: Kidney Stone Prevention
Grade D: Testosterone & Sexual Function
Grade D: Inflammation

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Pedalium murex

Quick Facts: Pedalium murex

Best Evidence:Grade C
Conditions Studied:0
Research Outcomes:3

Outcomes by grade:

0 conditions · 3 outcomes

Detailed Outcomes

Kidney Stone Prevention

Multiple preclinical studies consistently demonstrate anti-urolithiatic effects. In ethylene glycol-induced renal calculi models, fruit extract significantly reduced calcium oxalate crystal deposition. Ethyl acetate extract inhibited struvite crystal formation both in vitro and in vivo, and the active compound pedalitin significantly suppressed urease gene expression in Proteus mirabilis, a key pathogen in infection-related stone formation.

moderate↓Worsens

Testosterone & Sexual Function

In rodent models, ethanolic fruit extract significantly increased serum testosterone and improved sexual behavior parameters (mounting frequency, intromission frequency, ejaculation latency) compared to controls, with effects persisting after treatment withdrawal. A separate rat study found petroleum ether extract restored mating behavior and fertility parameters in ethanol-damaged male rats.

moderate↑Improves

Inflammation

In a rat paw edema model, ethanolic fruit extract at 200 mg/kg demonstrated 65.87% inhibition of inflammation at 180 minutes, comparable to diclofenac sodium. The extract also showed peripheral analgesic activity (72.13% inhibition of writhing) but lacked central analgesic or antipyretic effects.

moderate↓Improves

Research Citations (6)

Effect of traditionally used herb Pedalium murex L. and its active compound pedalitin on urease expression – For the management of kidney stone

Saudi Journal of Biological Sciences (2020)

PMID: 32127759

Evaluation of anti-urolithiatic potential of ethyl acetate extract of Pedalium murex L. on struvite crystal (kidney stone)

Journal of Traditional and Complementary Medicine (2018)

PMID: 30671363

Anti-urolithiatic effect of ethanolic extract of Pedalium murex linn. fruits on ethylene glycol-induced renal calculi

Urology Journal (2013)

PMID: 24078501

Evaluation of Anti-Inflammatory, Analgesic, and Antipyretic Effects of Ethanolic Extract of Pedalium Murex Linn. Fruits

African Journal of Traditional, Complementary, and Alternative Medicines (2013)

PMID: 24146508

A comparative study of ethanolic extracts of Pedalium murex Linn. fruits and sildenafil citrate on sexual behaviors and serum testosterone level in male rats during and after treatment

Journal of Ethnopharmacology (2012)

PMID: 22732724

Effect of ethanolic fruit extract of Pedalium murex Linn. in ethylene glycol induced urolithiasis in male Wistar albino rats

Ancient Science of Life (2010)

PMID: 22557365

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