Supplement
Pedalium murex is a flowering herb whose fruit has long been used in traditional medicine. Research has looked most at kidney stones, where animal and lab studies found the fruit extract reduced calcium oxalate crystal buildup and blocked struvite crystal formation, though the evidence is limited. Because this work is mostly animal or lab-based, it is still unclear whether people would see the same effects.
Sources: PMID 30671363; PMID 32127759
- Updated
- How we grade
- 6 studies cited
- Best evidence
- Grade C
- Conditions studied
- 0
- Outcomes
- 3
- Graded outcomes
- 0012
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Kidney Stone Prevention Multiple preclinical studies consistently demonstrate anti-urolithiatic effects. In ethylene glycol-induced renal calculi models, fruit extract significantly reduced calcium oxalate crystal deposition. Ethyl acetate extract inhibited struvite crystal formation both in vitro and in vivo, and the active compound pedalitin significantly suppressed urease gene expression in Proteus mirabilis, a key pathogen in infection-related stone formation. | Changes; see studies | Moderate effect | 4 studies | |||
Studies that measured kidney stone prevention
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| Testosterone & Sexual Function In rodent models, ethanolic fruit extract significantly increased serum testosterone and improved sexual behavior parameters (mounting frequency, intromission frequency, ejaculation latency) compared to controls, with effects persisting after treatment withdrawal. A separate rat study found petroleum ether extract restored mating behavior and fertility parameters in ethanol-damaged male rats. | Improves (the measure goes up) | Moderate effect | 1 study | |||
Studies that measured testosterone & sexual function | ||||||
| Inflammation In a rat paw edema model, ethanolic fruit extract at 200 mg/kg demonstrated 65.87% inhibition of inflammation at 180 minutes, comparable to diclofenac sodium. The extract also showed peripheral analgesic activity (72.13% inhibition of writhing) but lacked central analgesic or antipyretic effects. | Improves (the measure goes down) | Moderate effect | 1 study | |||
Studies that measured inflammation | ||||||
Key findings
- Kidney Stone PreventionChanges; see studies
- Testosterone & Sexual FunctionImproves (the measure goes up)
- InflammationImproves (the measure goes down)
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- Grade C
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Studies cited
6 studies from PubMed
- Effect of traditionally used herb Pedalium murex L. and its active compound pedalitin on urease expression – For the management of kidney stone
- Evaluation of anti-urolithiatic potential of ethyl acetate extract of Pedalium murex L. on struvite crystal (kidney stone)
- Anti-urolithiatic effect of ethanolic extract of Pedalium murex linn. fruits on ethylene glycol-induced renal calculi
- Evaluation of Anti-Inflammatory, Analgesic, and Antipyretic Effects of Ethanolic Extract of Pedalium Murex Linn. Fruits
- A comparative study of ethanolic extracts of Pedalium murex Linn. fruits and sildenafil citrate on sexual behaviors and serum testosterone level in male rats during and after treatment
- Effect of ethanolic fruit extract of Pedalium murex Linn. in ethylene glycol induced urolithiasis in male Wistar albino rats