OEA is an endogenous lipid signaling molecule produced in the intestines after fat consumption. Primary mechanism is PPARa activation (same receptor as fibrate drugs). Reliably reduces food intake in animal studies. Also activates GPR119 and TRPV1 receptors. Part of the endocannabinoid-like family but doesn't directly activate CB receptors. LIMITED human evidence - oral supplementation efficacy for weight loss unproven. Found naturally after olive oil consumption.
OEA is an endogenous lipid signaling molecule produced in the intestines after fat consumption. Primary mechanism is PPARa activation (same receptor as fibrate drugs).
No specific caution or interaction language was detected in the current summary/outcome notes.
Best grade per condition (each condition may have multiple outcomes)
3 shared conditions · 6 outcomes
White Kidney Bean extract (Phase 2) is an alpha-amylase inhibitor that blocks starch digestion. It DOES work but potency is variable and modest - blocks ~25-65% of starch calories in acute studies. Meta-analyses show ~2kg weight loss over 4-12 weeks. Must be taken with starchy meals. Undigested starch goes to colon bacteria (gas, bloating). Better for preventing weight gain than losing existing weight. Works best with high-starch meals.
2 shared conditions · 197 outcomes
Whey protein is one of the two high-quality proteins derived from cow’s milk (casein being the other). Its high digestibility, quick absorption, and well-researched benefits for muscle gain and cardiometabolic health make it a popular protein supplement among athletes and older adults.
2 shared conditions · 7 outcomes
Valine is one of three branched-chain amino acids (BCAAs), along with leucine and isoleucine. It's essential (must come from diet). NO GRADED OUTCOMES for isolated valine. Least studied and likely least important of the BCAAs for muscle building. Generally supplemented as part of BCAA mixture rather than alone. No unique proven benefits compared to other BCAAs. Safe as an amino acid. Adequate protein intake typically provides sufficient valine.
2 shared conditions · 6 outcomes
Sacred Lotus (Nelumbo nucifera) is an aquatic plant important in Asian cuisine and traditional medicine. All parts are used - seeds, leaves, rhizomes, flowers. Rich in polyphenols (catechins, procyanidins) and contains unique alkaloids like neferine. Preclinical research suggests anti-diabetic, anti-obesity, anti-depressant, and sedative effects. NO human clinical trials. Most interesting bioactive is neferine (unique to this plant) which shows various pharmacological effects in vitro. Remains underresearched in humans.
2 shared conditions · 2 outcomes
Rauwolscine is a diastereoisomer (stereoisomer) of yohimbine with similar alpha-2 adrenergic antagonist activity. May be more potent than yohimbine at the same receptor. Used in fat burner supplements for 'stubborn fat' areas. Like yohimbine, works by blocking alpha-2 receptors that inhibit fat release. VERY LIMITED human research - potency and safety extrapolated from yohimbine data. Likely shares yohimbine's stimulant side effects (anxiety, elevated heart rate).
2 shared conditions · 9 outcomes
Piperine is the pungent alkaloid from black pepper (Piper nigrum). Primary use is as a bioavailability enhancer - increases absorption of many supplements (curcumin by 2000%, CoQ10, resveratrol, etc.) by inhibiting drug-metabolizing enzymes and transporters. IMPORTANT: Same mechanism that increases supplement absorption also affects medications - significant drug interaction potential. As a standalone supplement, has mild thermogenic and metabolic effects. BioPerine is a standardized 95% piperine extract.
2 shared conditions · 8 outcomes
Piceatannol is a stilbene compound similar to resveratrol, found in passion fruit, grapes, and berries. Also a metabolite of resveratrol. May have superior bioavailability and bioactivity compared to resveratrol in some studies. Unique SIRT1 activation and AMPK effects. Preliminary human studies suggest benefits for insulin sensitivity. Less studied than resveratrol but potentially more promising. Contains extra hydroxyl group giving stronger antioxidant activity.
2 shared conditions · 10 outcomes
NAD+ is a critical coenzyme involved in cellular energy metabolism, DNA repair, and aging-related pathways. NAD+ levels decline with age, driving interest in supplementation for anti-aging. However, oral NAD+ itself has very poor bioavailability - PRECURSORS like NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are generally preferred. NO GRADED OUTCOMES for direct NAD+ supplementation. Most NAD+ research actually uses precursors. Research on aging benefits is ongoing but preliminary.