Multivitamin

Automated reading of the published studies (Decosa evidence engine), for outcomes Dr. Grey has not graded yet. It is not a Dr. Grey grade and does not change one. How it is read

• Fatigue

  The studies disagree. The best available review (2013, 20 studies) found little or no difference in fatigue, while 2 of the 4 studies read found an improvement. The evidence is very weak.

  4 studies counted of 10 read: 2 reviews and 2 trials (54 people in the trials).

  1. Systematic review, 2013; 20 studies; cancer patients undergoing treatment: no clear difference (the review the verdict rests on). multivitamins are ineffective at reducing cancer-related fatigue A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatiguePubMed 23632236
  2. Meta-analysis, 2013; 8 studies; nonclinical samples: improves. Fatigue (SMD=0.27; 95% CI=0.40-0.146; p<.001) and confusion (SMD=0.225; 95% CI=0.38-0.07; p<.003) were also reduced. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysisPubMed 23362497
  3. Crossover trial, 2007; 40 people; breast cancer patients undergoing radiation therapy: no clear difference. No significant changes were elicited with the use of multivitamins Multivitamins do not improve radiation therapy-related fatigue: results of a double-blind randomized crossover trialPubMed 17762445
  4. Crossover trial, 2006; 14 people; resistance-trained men: improves. decreased rate of fatigue was noted Effect of a liquid multivitamin/mineral supplement on anaerobic exercise performancePubMed 16700404

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

• Respiratory infections

  The studies disagree. The best available review (2006, 20 studies) did not settle it for respiratory infections, while 1 of the 2 studies read found no clear answer. The evidence is very weak.

  Side effects: 1 of the 3 studies that reported on them found more with Multivitamin (non-serious adverse events).

  2 studies counted of 10 read: 2 reviews.

  1. Meta-analysis, 2006; 20 studies: mixed results (the review the verdict rests on). significantly less episodes of infection in those supplemented A systematic review of multivitamin and multimineral supplementation for infectionPubMed 16756533
  2. Meta-analysis, 2005; 8 studies; elderly people: unclear: evidence too weak to tell. Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trialsPubMed 15805125

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.