Supplement
Hyaluronic acid is a gel-like sugar molecule found naturally in skin, joints, and eyes, where it holds large amounts of water and keeps tissues lubricated. Most people look at it for dry eye, and a pooled analysis of eye drops found dry eye symptoms improved, with moderate evidence behind that result. The effect was small, though, and it came from a single analysis of 582 people, so it speaks to eye drops rather than to capsules or pills.
Sources: PMID 33804439
- Updated
- How we grade
- 2 studies cited
- Best evidence
- Grade B
- Conditions studied
- 3
- Outcomes
- 5
- Graded outcomes
- 0300
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Dry Eye Symptoms Small Improvement | Improves (the measure goes down) | Small effect | 1 study | 582 people | ||
Studies that measured dry eye symptoms | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Dermatitis Severity Moderate Improvement | Improves (the measure goes down) | Moderate effect | 1 study | 104 people | ||
Studies that measured dermatitis severity | ||||||
| Mucositis Symptoms | Improves (the measure goes down) | 107 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Dermatitis Severity Moderate Improvement | Improves (the measure goes down) | Moderate effect | 1 study | 104 people | ||
Studies that measured dermatitis severity | ||||||
| Mucositis Symptoms | Improves (the measure goes down) | 107 people | ||||
Key findings
- Dry Eye SymptomsImproves (the measure goes down)
- Dermatitis SeverityImproves (the measure goes down)
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Third-party tested Hyaluronic Acid products, in the forms the graded studies used where we can match them.
- Grade B
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Studies cited
2 studies from PubMed