Huperzine A
Huperzine A is a potent, reversible acetylcholinesterase inhibitor from Chinese club moss. Meta-analysis of 20 RCTs (n=1823) shows significant cognitive benefits in Alzheimer's patients. Also has weak NMDA receptor antagonism and neuroprotective effects. Licensed as AD drug in China; available as nutraceutical in US. Higher doses (400 mcg BID) more effective than lower doses. Wide safety margin - non-toxic at 50-100x therapeutic dose.
Quick Answer
What it is
Huperzine A is a potent, reversible acetylcholinesterase inhibitor from Chinese club moss. Meta-analysis of 20 RCTs (n=1823) shows significant cognitive benefits in Alzheimer's patients.
Key findings
- Grade B: Cognitive Function (MMSE) (Alzheimer’s Disease)
- Grade B: Memory (WMS) (Alzheimer’s Disease)
- Grade B: Cognitive Function (ADAS-Cog) (Alzheimer’s Disease)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Huperzine A
Quick Facts: Huperzine A
- Best Evidence:Grade B
- Conditions Studied:1
- Research Outcomes:6
- Grade B Findings:3
- Key Effect:Alzheimer’s Disease
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (5)
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