Aniracetam
Aniracetam is a fat-soluble pyrrolidinone racetam that acts as a positive allosteric modulator of AMPA receptors, slowing desensitization and enhancing synaptic plasticity in hippocampal CA1 and dentate gyrus regions. One open-label study (n=276) showed maintained cognition at 12 months and improved emotional state vs cholinesterase inhibitors in mild dementia. Prescribed in Greece/Italy for cognitive disorders. Withdrawn from Japan after failed placebo-controlled trial. Not FDA-approved in US.
Quick Answer
What it is
Aniracetam is a fat-soluble pyrrolidinone racetam that acts as a positive allosteric modulator of AMPA receptors, slowing desensitization and enhancing synaptic plasticity in hippocampal CA1 and dentate gyrus regions. One open-label study (n=276) showed maintained cognition at 12 months and improved emotional state vs cholinesterase inhibitors in mild dementia.
Key findings
- Grade C: Cognitive Function (MMSE)
- Grade C: Emotional State (Dementia)
- Grade C: Functionality (Dementia)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Aniracetam
Quick Facts: Aniracetam
- Best Evidence:Grade C
- Conditions Studied:1
- Research Outcomes:3
- Key Effect:Dementia
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (4)
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