Protocol · Respiratory/ENT Health
Sinusitis Support Protocol
Serrapeptase and N-Acetyl Cysteine (NAC) are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Sinusitis Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Serrapeptase | Amount listed: 60,000–120,000 SPU daily on empty stomach | Proteolytic enzyme that may thin mucus and reduce inflammation in sinuses
| Not graded yet | ||
| N-Acetyl Cysteine (NAC) | Amount listed: 600–1,200 mg daily | Mucolytic agent; thins mucus and supports drainage; antioxidant properties | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Bromelain | Amount listed: 500–1,000 mg daily between meals | Anti-inflammatory enzyme; may reduce swelling and improve sinus drainage | Not graded yet | ||
| Vitamin C | Amount listed: 1,000–2,000 mg daily | Immune support; antioxidant; may reduce duration of respiratory infections | Not graded yet | ||
| Quercetin | Amount listed: 500–1,000 mg daily | Natural antihistamine; anti-inflammatory; may reduce allergic component | Not graded yet | ||
| Zinc | Amount listed: 15–30 mg daily | Immune support; may reduce duration of upper respiratory infections | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Sinusitis is inflammation of the sinuses, the air-filled spaces behind your forehead, cheeks, nose, and between your eyes. It can be acute (short-term) or chronic (lasting 12+ weeks).
TYPES:
- Acute sinusitis: Usually from viral cold; lasts <4 weeks
- Subacute sinusitis: 4-12 weeks
- Chronic sinusitis: >12 weeks; often with polyps
- Recurrent acute: 4+ episodes per year
SYMPTOMS:
- Facial pain/pressure (worse bending forward)
- Nasal congestion and discharge
- Reduced sense of smell
- Post-nasal drip
- Headache
- Fever (acute bacterial)
CAUSES:
- Viral infection (most common)
- Bacterial infection (complicating viral)
- Allergies
- Nasal polyps
- Deviated septum
- Fungal (rare)
WHEN TO SEE A DOCTOR:
- Symptoms >10 days without improvement
- High fever (>102°F/39°C)
- Severe headache or facial pain
- Visual changes
- Symptoms that worsen after initial improvement
FIRST-LINE TREATMENTS:
- Saline irrigation: Most important; flushes sinuses
- Intranasal corticosteroids: Reduce inflammation
- Decongestants: Short-term only (3-5 days)
- Antibiotics: Only if bacterial infection suspected
NAC* helps thin mucus for better drainage.
Serrapeptase and bromelain* may reduce inflammation.
Immune support* with vitamin C and zinc.
Expected timeline: Acute sinusitis usually resolves in 7-10 days. Supplements may help with symptom relief and recovery.