Protocol · Cardiovascular Health
Pulmonary Hypertension Supportive Care Protocol
Coenzyme Q10 and Iron are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Pulmonary Hypertension Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Coenzyme Q10 | Amount listed: 100–300 mg daily | Supports cardiac energy production; antioxidant; may help with exercise tolerance and heart function | Not graded yet | ||
| Iron | Amount listed: IV iron if deficient (oral often inadequate); dosing per physician | Iron deficiency very common in PAH and worsens exercise capacity; supplementation improves symptoms | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory; may support vascular health and reduce inflammation | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (monitor levels) | Deficiency common in PAH; may support immune function and vascular health | Not graded yet | ||
| L-Arginine | Amount listed: 3–6 g daily (ONLY under physician supervision) | Nitric oxide precursor; may support vasodilation (use with caution - discuss with physician) | Not graded yet | ||
| Magnesium | Amount listed: 300–400 mg daily | Supports cardiovascular function; vasodilator properties; often depleted in heart failure | Not graded yet | ||
| L-Carnitine | Amount listed: 1–2 g daily | Supports cardiac energy metabolism; may help with exercise tolerance | Not graded yet | ||
| B-Complex Vitamins | Amount listed: B-complex with methylated B12 and folate daily | Support energy metabolism; B12 and folate important for homocysteine metabolism | Not graded yet | ||
| Taurine | Amount listed: 1–3 g daily | Supports cardiac function; antioxidant; may have mild vasodilatory effects | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Pulmonary Hypertension. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Pulmonary hypertension (PH) is high blood pressure in the blood vessels of the lungs. Unlike regular high blood pressure (systemic), PH specifically affects the pulmonary arteries. This increases the workload on the right side of the heart, which can eventually lead to right heart failure. Symptoms include shortness of breath (especially with exertion), fatigue, chest pain, dizziness, leg swelling, and racing heartbeat.
CRITICAL: Pulmonary hypertension is a serious, life-threatening condition requiring specialist care from a pulmonologist and/or cardiologist experienced in PH. There are 5 groups of PH with different causes and treatments:
- Group 1 (PAH): Pulmonary arterial hypertension - treated with targeted therapies
- Group 2: Due to left heart disease
- Group 3: Due to lung disease/hypoxia
- Group 4: Chronic thromboembolic (CTEPH)
- Group 5: Unclear/multifactorial
MEDICAL TREATMENT IS ESSENTIAL. For Group 1 PAH, approved therapies include: phosphodiesterase inhibitors (sildenafil, tadalafil), endothelin receptor antagonists (bosentan, ambrisentan), prostacyclin analogs (epoprostenol, treprostinil), and soluble guanylate cyclase stimulators (riociguat). Treatment is complex and often involves combination therapy.
These supplements are SUPPORTIVE ONLY and must be discussed with your PH specialist:
Iron* deficiency is extremely common in PAH (affecting 40-60% of patients) and independently worsens exercise capacity. IV iron replacement (oral often ineffective) can significantly improve symptoms.
Coenzyme Q10* supports heart energy production.
Omega-3 Fatty Acids* may support vascular health.
L-Arginine* is a nitric oxide precursor - use ONLY under physician supervision as it can interact with PH medications.
Magnesium and L-Carnitine* support cardiovascular function.
Expected outcomes: These supplements may provide modest supportive benefit but DO NOT replace medical therapy. Work closely with your PH specialist team.