Protocol · Mental Health & Mood
Panic Disorder Supportive Care Protocol
Inositol and Lavender Oil (Silexan) are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Panic Disorder Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · 1 graded · 2 confirmed studies
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Inositol | Amount listed: 12–18 g daily in divided doses (start lower, titrate up) | Acts as second messenger in serotonin system; significantly reduces panic attack frequency in clinical trials
| Grade B for Anxiety Symptoms3 studies · 41 people | ||
Confirmed studies for Inositol (titles as PubMed lists them) | |||||
| Lavender Oil (Silexan) | Amount listed: 80–160 mg Silexan daily | Proprietary lavender extract with demonstrated anxiolytic effects comparable to low-dose benzodiazepines | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Magnesium | Amount listed: 300–400 mg daily (glycinate or threonate for calming effects) | Modulates GABA and glutamate; deficiency associated with anxiety; supplementation may reduce panic symptoms | Not graded yet | ||
| L-Theanine | Amount listed: 100–400 mg daily or as needed | Amino acid from tea that increases alpha brain waves and promotes calm without sedation | Not graded yet | ||
| Passionflower | Amount listed: 250–500 mg extract daily or as needed | GABA-ergic herb with anxiolytic effects; may help with acute anxiety symptoms | Not graded yet | ||
| Ashwagandha | Amount listed: 300–600 mg standardized extract daily | Adaptogen that reduces cortisol and anxiety; may help with chronic stress component of panic | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily (higher EPA may be more effective for mood) | Anti-inflammatory effects on brain; may reduce anxiety symptoms | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (target 40–60 ng/mL) | Deficiency associated with anxiety; vitamin D receptors in brain regions involved in mood | Not graded yet | ||
| B Vitamins | Amount listed: B-complex with high B6 (50–100 mg), B12, and folate | Support neurotransmitter synthesis; may help with stress resilience | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The supplement in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.
- Grade B
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How this protocol works
In plain language
Panic disorder is characterized by recurrent, unexpected panic attacks - sudden surges of intense fear or discomfort with physical symptoms like racing heart, shortness of breath, chest pain, dizziness, and fear of dying or losing control. People with panic disorder often develop anticipatory anxiety (fear of the next attack) and may avoid situations where attacks have occurred. It affects about 2-3% of the population and is highly treatable with therapy and/or medication.
CRITICAL: Panic attacks can mimic serious medical conditions like heart attacks. New or severe symptoms should be medically evaluated. Panic disorder responds very well to Cognitive Behavioral Therapy (CBT), which is considered first-line treatment. SSRIs and benzodiazepines are effective medications. These supplements may help but should not delay evidence-based treatment. If panic attacks are frequent or impairing your life, see a mental health professional.
Inositol* has the strongest supplement evidence for panic disorder. It works through the serotonin system similar to SSRIs. Clinical trials show high-dose inositol (12-18g/day) significantly reduces panic attack frequency, comparable to fluvoxamine. Start with lower doses to avoid GI side effects.
Lavender Oil (Silexan)* is a standardized lavender extract with proven anxiolytic effects. Multiple trials show it reduces anxiety comparable to low-dose lorazepam but without sedation or dependence risk.
Magnesium* deficiency is associated with increased anxiety. Magnesium modulates GABA (the calming neurotransmitter) and supplementation may help reduce panic symptoms.
L-Theanine* is an amino acid from green tea that increases calming alpha brain waves. It promotes relaxation without sedation and can be taken as needed for acute anxiety.
Passionflower* has GABA-ergic effects and may help with acute anxiety symptoms.
Ashwagandha* is an adaptogen that reduces cortisol levels. It may help address the chronic stress component of panic disorder.
Omega-3 Fatty Acids* have anti-inflammatory effects on the brain and may help reduce anxiety symptoms.
Vitamin D* deficiency is associated with anxiety disorders. Maintaining adequate levels supports overall mental health.
B Vitamins* support neurotransmitter synthesis and stress resilience.
Expected timeline: Inositol: 4-8 weeks for full effect. Lavender: 2-4 weeks. L-theanine and passionflower: can work acutely. Magnesium: 4-8 weeks for nervous system support. CBT typically shows improvement in 12-16 sessions.