Protocol · Metabolic Health
Hyperuricemia (High Uric Acid) Management Protocol
Vitamin C and Tart Cherry Extract are the core of this stack, with 5 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Hyperuricemia (High Uric Acid) Management.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
7 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Vitamin C | Amount listed: 500–1,500 mg daily | Increases uric acid excretion; lowers serum uric acid levels in studies
| Not graded yet | ||
| Tart Cherry Extract | Amount listed: 240–480 ml juice daily or 500–1,000 mg extract | Contains anthocyanins that may inhibit xanthine oxidase and reduce uric acid | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Quercetin | Amount listed: 500 mg twice daily | Inhibits xanthine oxidase; may reduce uric acid production | Not graded yet | ||
| Folic Acid | Amount listed: 5 mg daily (higher dose for effect) | May inhibit xanthine oxidase; some studies show uric acid reduction | Not graded yet | ||
| Celery Seed Extract | Amount listed: 75–150 mg twice daily | Traditional remedy; may help lower uric acid and reduce inflammation | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2 g EPA+DHA daily | Anti-inflammatory; may help with gout symptoms if hyperuricemia progresses | Not graded yet | ||
| Bromelain | Amount listed: 500–1,000 mg daily between meals | Anti-inflammatory; may help reduce inflammation associated with high uric acid | Not graded yet | ||
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How this protocol works
In plain language
Hyperuricemia is elevated uric acid levels in the blood (typically >6.8 mg/dL in men, >6 mg/dL in women). Uric acid is produced when the body breaks down purines (found in certain foods and drinks). High levels can lead to gout (painful crystal deposits in joints) and kidney stones.
WHY URIC ACID RISES:
- Overproduction: High purine diet, genetic factors
- Underexcretion: Most common cause (kidneys don't excrete enough)
- Combined: Both mechanisms together
RISK FACTORS:
- Diet high in purines (red meat, organ meats, shellfish)
- Alcohol, especially beer
- Fructose and sugary drinks
- Obesity
- Kidney disease
- Certain medications (diuretics, low-dose aspirin)
- Metabolic syndrome
CONSEQUENCES:
- Gout attacks
- Kidney stones
- May contribute to cardiovascular and kidney disease
DIETARY MODIFICATIONS:
- Reduce high-purine foods
- Limit alcohol (especially beer)
- Reduce fructose/sugar intake
- Stay well hydrated
- Include low-fat dairy (protective)
- Coffee may be protective
WHEN MEDICATION IS NEEDED:
- Recurrent gout attacks
- Tophi (uric acid deposits)
- Kidney stones
- Very high levels with complications
Vitamin C* can lower uric acid by about 0.5 mg/dL at higher doses.
Tart cherry* has shown uric acid-lowering effects and gout prevention.
Quercetin* may inhibit the enzyme that produces uric acid.
Expected timeline: Dietary and supplement interventions may take 4-8 weeks to show measurable effects on uric acid levels.