Protocol · Digestive
H. Pylori Infection Protocol
Saccharomyces boulardii and Lactobacillus reuteri are the core of this stack, with 3 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in H. Pylori Infection.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
5 supplements · 1 graded · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Saccharomyces boulardii | Amount listed: 500–1,000 mg daily | Probiotic yeast that reduces H. pylori colonization and antibiotic side effects | Not graded yet | ||
| Lactobacillus reuteri | Amount listed: 200 million CFU daily (DSM 17,938 strain) | Produces reuterin, a direct antimicrobial against H. pylori, and competes for adhesion
| Grade B for Helicobacter Pylori Infection Signs3 studies · 1,087 people | ||
| Supporting stackListed as additions to the core | |||||
| Mastic Gum | Amount listed: 1,000 mg daily (divided doses) | Natural resin with direct bactericidal activity against H. pylori strains | Not graded yet | ||
| Sulforaphane (Broccoli Sprout Extract) | Amount listed: 30–60 mg sulforaphane daily (or 100 g fresh broccoli sprouts) | Activates Nrf2 antioxidant pathway and has direct anti-H. pylori effects | Not graded yet | ||
Confirmed studies for Sulforaphane (Broccoli Sprout Extract) (titles as PubMed lists them) | |||||
| Vitamin C | Amount listed: 500 mg twice daily | Creates acidic environment unfavorable to H. pylori and reduces gastric inflammation | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for H. Pylori Infection. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The supplement in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.
- Grade B
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How this protocol works
In plain language
H. pylori is a stomach bacteria that causes ulcers, gastritis, and increases stomach cancer risk. While antibiotics are the primary treatment, these supplements can significantly boost eradication rates and reduce antibiotic side effects.
- Saccharomyces boulardii is a probiotic yeast that survives stomach acid and competes with H. pylori for nutrients. When added to standard triple therapy, it increases eradication rates by 10-15% and dramatically reduces diarrhea from antibiotics.
- Lactobacillus reuteri produces reuterin, a natural antibiotic that directly kills H. pylori. The DSM 17938 strain is best studied.
- Mastic gum is a Mediterranean tree resin with direct bactericidal activity. Some patients achieve eradication with mastic alone, though it's best used alongside antibiotics.
- Sulforaphane from broccoli sprouts reduces H. pylori colonization by 40% in some studies—it works by activating the body's own antimicrobial defenses.
- Vitamin C creates an acidic gastric environment less hospitable to H. pylori.
Expected timeline: Use probiotics 2 weeks before, during, and 2 weeks after antibiotic treatment. Retest H. pylori 4-6 weeks after completing therapy.