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Dr. Grey AI

Protocol · Sports & Performance

Cycling Performance Protocol

Caffeine and Beetroot Juice (Nitrate) are the core of this stack, with 2 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Cycling Performance.

We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.

The stack

4 supplements · 3 graded · 1 graded A

Amount listed in this protocol; not a recommendation.

Supplements in the Cycling Performance protocol, with the amount the protocol lists, the grade on file and confirmed studies
GradeSupplementAmount listedWhy it’s in the stackEvidence on fileShop
Primary stackThe core of this protocol
CaffeineAmount listed: 3–6 mg/kg body weight, 30–60 min pre-ride

Adenosine antagonist that reduces perceived exertion, enhances fat oxidation, and improves endurance capacity

  • Aerobic Exercise Metrics: improves
  • Anaerobic Capacity: improves
  • Blood Lactate (Exercise): changes; see studies
  • Heart Rate: changes; see studies
  • Power Output: improves
Grade A for Aerobic Exercise Metrics4 studies · 218 people
Beetroot Juice (Nitrate)Amount listed: 6–8 mmol nitrate (500 ml beetroot juice) 2–3h pre-exercise

Increases nitric oxide production, improving oxygen efficiency and reducing the ATP cost of exercise

Not graded yet
Supporting stackListed as additions to the core
Beta-AlanineAmount listed: 3.2–6.4 g daily for 4+ weeks

Increases muscle carnosine, buffering acid during sustained high-intensity efforts

  • Anaerobic Capacity: improves
  • Muscular Endurance: improves
  • Power Output: improves
  • Oxygen Uptake: improves
  • Fatigue Symptoms: changes; see studies
Grade C for Anaerobic Capacity2 studies · 20 people
Sodium BicarbonateAmount listed: 0.3 g/kg body weight, 60–90 min pre-exercise

Extracellular buffer that delays fatigue during high-intensity cycling efforts and sprints

  • Aerobic Exercise Metrics: improves
  • Adrenaline: studied
  • Serum Bicarbonate: improves
  • Anaerobic Capacity: improves
  • Power Output: improves
Grade C for Aerobic Exercise Metrics6 people

Shop the evidence-backed picks

Fullscript collectionMuscle, performance and healthy ageing: evidence-graded picksOpen on Fullscript

Or shop one supplement

The supplement in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.

  • Grade A

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How this protocol works

In plain language

Cycling performance depends on aerobic power (VO2max), efficiency, lactate threshold, and the ability to sustain high intensities during climbs, breakaways, and sprints. This protocol targets all these factors with the most evidence-backed ergogenic aids in cycling research.

  • Caffeine is the most reliable performance enhancer for cycling. It reduces perceived exertion (making hard efforts feel easier), increases fat burning (sparing glycogen), and improves focus. Studies consistently show 2-4% improvements in time trial performance—a massive margin in competitive cycling.
  • Beetroot Juice (Nitrate) has revolutionized endurance sports nutrition. Dietary nitrate is converted to nitric oxide, which improves the efficiency of oxygen use in muscles. This means you can maintain the same power output with less oxygen—or go faster at the same effort. Effects are most pronounced at altitude.
  • Beta-Alanine is beneficial for cycling efforts that push into the anaerobic zone—climbs, attacks, and sprint finishes. By increasing muscle carnosine, it buffers the acid that accumulates during these high-intensity efforts.
  • Sodium Bicarbonate provides additional buffering capacity for intense efforts lasting 1-7 minutes. It's particularly useful for criterium racing, short time trials, and mountain-top finishes.

Expected timeline: Caffeine works acutely (peak 30-60 min). Beetroot juice is best used 2-3 hours pre-exercise. Beta-alanine requires 4+ weeks of daily supplementation. Test GI tolerance with bicarbonate before race day.

Printed from drgrey.ai/protocols/cycling-performance. For education only; not medical advice. Talk to a clinician before starting any supplement.