Protocol · Mental Health
Cocaine Use Disorder Recovery Support Protocol
N-Acetyl Cysteine (NAC) and Omega-3 Fatty Acids are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Cocaine Use Disorder Recovery Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| N-Acetyl Cysteine (NAC) | Amount listed: 1,200–2,400 mg daily in divided doses | Modulates glutamate; reduces cocaine cravings; most studied supplement for cocaine use disorder
| Not graded yet | |
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA+DHA daily | Supports brain health and dopamine function; may reduce impulsivity; anti-inflammatory effects | Not graded yet | |
| Supporting stackListed as additions to the core | ||||
| B-Complex Vitamins | Amount listed: B-complex daily | Often depleted with cocaine use; supports energy and neurotransmitter synthesis | Not graded yet | |
| Vitamin D | Amount listed: 2,000–4,000 IU daily (test and correct deficiency) | Deficiency common; supports mood and dopamine synthesis | Not graded yet | |
| Magnesium | Amount listed: 300–400 mg daily | Supports GABA function; helps with anxiety and sleep during recovery | Not graded yet | |
| Zinc | Amount listed: 15–30 mg daily | Often deficient; supports immune function and neurotransmitter balance | Not graded yet | |
| Vitamin C | Amount listed: 1,000–2,000 mg daily | Antioxidant; depleted by cocaine use; supports adrenal function and dopamine synthesis | Not graded yet | |
| Tyrosine | Amount listed: 500–2,000 mg daily (morning, away from protein) | Dopamine precursor; may help restore dopamine system depleted by cocaine | Not graded yet | |
| Probiotics | Amount listed: 10–20 billion CFU daily | Gut-brain axis support; cocaine use disrupts gut microbiome | Not graded yet | |
How this protocol works
In plain language
Cocaine use disorder is characterized by compulsive cocaine use despite negative consequences. Cocaine is a powerful stimulant that floods the brain with dopamine, creating intense euphoria. Over time, the brain adapts by reducing dopamine receptors and production, leading to tolerance, craving, and difficulty experiencing pleasure without the drug.
CRITICAL: Cocaine use disorder requires professional treatment. This protocol is SUPPORTIVE ONLY.
EVIDENCE-BASED TREATMENT includes:
- Cognitive Behavioral Therapy (CBT): Identifies triggers, develops coping strategies
- Contingency Management: Rewards for negative drug tests
- Community Reinforcement Approach: Restructures social environment
- 12-Step Programs: Peer support (Cocaine Anonymous)
- Intensive Outpatient or Residential Programs: For severe addiction
IMPORTANT: There are no FDA-approved medications specifically for cocaine addiction, unlike opioid or alcohol use disorders. Research is ongoing.
IF IN CRISIS:
- SAMHSA National Helpline: 1-800-662-4357 (free, confidential, 24/7)
- Crisis Text Line: Text HOME to 741741
N-Acetyl Cysteine (NAC)* is the most studied supplement for cocaine addiction. It modulates glutamate (a neurotransmitter involved in craving) and has shown benefit in reducing cravings and cocaine use.
Omega-3 Fatty Acids* support brain health and may help with impulsivity.
B Vitamins and other nutrients* are often depleted by cocaine use and poor nutrition during addiction.
Expected timeline: Recovery is a long process. NAC may reduce cravings within 4-8 weeks. Full dopamine system recovery can take months to years. Relapse is common and is part of recovery - not failure.