Protocol · Immune System
Allergic Diseases General Support Protocol
Quercetin and Probiotics are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Allergic Diseases General Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · none graded yet · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Quercetin | Amount listed: 500–1,000 mg daily in divided doses | Natural antihistamine; stabilizes mast cells and reduces histamine release; anti-inflammatory | Not graded yet | ||
Confirmed studies for Quercetin (titles as PubMed lists them) | |||||
| Probiotics | Amount listed: 10–20 billion CFU multi-strain daily (Lactobacillus and Bifidobacterium strains) | Modulate immune response and reduce Th2 dominance associated with allergies; particularly helpful for prevention | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (target 40–60 ng/mL) | Immunomodulatory effects; deficiency associated with increased allergy prevalence | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 1–3 g EPA+DHA daily | Anti-inflammatory; may reduce allergic inflammation by modulating immune response | Not graded yet | ||
| Vitamin C | Amount listed: 1,000–2,000 mg daily in divided doses | Natural antihistamine; reduces histamine levels and allergic symptoms | Not graded yet | ||
| Butterbur (Petasites) | Amount listed: 75–150 mg PA-free butterbur extract daily | Inhibits leukotrienes; shown to be as effective as antihistamines for allergic rhinitis | Not graded yet | ||
| Stinging Nettle | Amount listed: 300–900 mg dried leaf extract daily | Natural antihistamine and anti-inflammatory; traditionally used for hay fever | Not graded yet | ||
| Bromelain | Amount listed: 500–1,000 mg daily between meals | Anti-inflammatory enzyme that may reduce nasal swelling and improve breathing | Not graded yet | ||
| N-Acetyl Cysteine (NAC) | Amount listed: 600–1,200 mg daily | Mucolytic that thins mucus; reduces nasal congestion and sinus symptoms | Not graded yet | ||
Shop the evidence-backed picks
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How this protocol works
In plain language
Allergic diseases occur when the immune system overreacts to normally harmless substances (allergens) like pollen, dust mites, pet dander, or certain foods. This includes conditions like allergic rhinitis (hay fever), allergic asthma, eczema, and food allergies. The allergic response involves the release of histamine and other inflammatory chemicals, causing symptoms like sneezing, itching, hives, swelling, and in severe cases, anaphylaxis. Treatment focuses on avoiding triggers and controlling symptoms.
CRITICAL: Severe allergic reactions (anaphylaxis) are life-threatening emergencies requiring immediate epinephrine. If you have known severe allergies, always carry an epinephrine auto-injector. See an allergist for proper diagnosis and management - allergen immunotherapy can provide long-term relief. Antihistamines and nasal corticosteroids are first-line treatments. These supplements may help reduce symptoms but don't replace emergency medications or proven treatments.
Quercetin* is a natural flavonoid that acts as an antihistamine by stabilizing mast cells and reducing histamine release. It also has anti-inflammatory effects. Taking it regularly, especially before allergy season, may reduce symptoms.
Probiotics* help balance the immune system. Allergies are associated with immune system imbalance (Th2 dominance). Specific probiotic strains have been shown to reduce allergic rhinitis symptoms and may help prevent allergies in children.
Vitamin D* modulates the immune system. Deficiency is associated with increased allergy prevalence and severity. Maintaining adequate levels supports balanced immune function.
Omega-3 Fatty Acids* have anti-inflammatory effects that may reduce allergic inflammation and symptoms.
Vitamin C* acts as a natural antihistamine by helping to break down histamine. Higher blood levels of vitamin C are associated with lower histamine levels.
Butterbur* inhibits leukotrienes, inflammatory chemicals involved in allergic reactions. Studies show PA-free butterbur extract can be as effective as antihistamines for allergic rhinitis without causing drowsiness.
Stinging Nettle* has been traditionally used for hay fever and may reduce allergic rhinitis symptoms through antihistamine effects.
Bromelain* is an anti-inflammatory enzyme that may reduce nasal swelling and improve breathing.
NAC* is a mucolytic that thins mucus, helping to relieve nasal congestion and sinus symptoms.
Expected timeline: Quercetin and butterbur may show effects within 1-2 weeks. Vitamin C can help acutely. Probiotics typically need 4-8 weeks for immune modulation. Starting supplements before allergy season (2-4 weeks prior) can be helpful for seasonal allergies.