Condition

Raynaud's Phenomenon

Raynaud's phenomenon is a condition in which blood vessels in the fingers and toes narrow in response to cold or stress, turning the skin white, then blue, then red as blood flow returns. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Omega-3 fatty acids and ginkgo biloba are often discussed for circulation, but that is still a hypothesis.

Supplements studied: 2
Graded outcomes: 0
Trials: 4
People studied: 432

Evidence by supplement

Strong
Moderate
Limited
Very limited

2 supplements

Ginkgo Biloba

Ginkgo Biloba: outcomes studied for Raynaud's Phenomenon
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Raynaud's Phenomenon Symptoms	Improves (the measure goes down)		2 studies	105 people
Studies that measured raynaud's phenomenon symptoms No significant effect of ginkgo biloba special extract EGb 761 in the treatment of primary Raynaud phenomenon: a randomized controlled trialJ Cardiovasc Pharmacol · PMID 22030896 To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phenomenon in South Korea; Korean Raynaud study (KOARA study)Clin Rheumatol · PMID 19159999

Fish Oil

Fish Oil: outcomes studied for Raynaud's Phenomenon
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Raynaud's Phenomenon Symptoms	Improves (the measure goes down)		1 study	32 people
Studies that measured raynaud's phenomenon symptoms Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study.Am J Med · PMID 2536517

The Raynaud's Phenomenon Support protocol

2 primary supplements · 3 supporting supplements

Omega-3 Fatty Acids3–4 g EPA+DHA daily
Ginkgo Biloba120–240 mg standardized extract daily

See the full protocol

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Studies cited

2 studies from PubMed

"Beet" the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud's phenomenon.J Appl Physiol, 1985 · PMID 31343948
The use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials.Acupunct Med · PMID 35608095