Condition
Paranoia
Paranoia is a pattern of persistent, unfounded beliefs that others mean you harm, such as feeling watched, followed or talked about, and it can arise from severe stress, sleep loss, substance use, or conditions like schizophrenia and bipolar disorder. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Omega-3 fatty acids and vitamin D have been looked at most often in related psychosis research, but that work isn't specific to paranoia.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 32
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anxiety Symptoms | Improves (the measure goes down) | 5 studies | 32 people | |||
Studies that measured anxiety symptoms
| ||||||
The Paranoia Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Omega-3 Fatty Acids2–4 g EPA+DHA daily (higher EPA ratio)
- Vitamin D2,000–4,000 IU daily (target 40–60 ng/mL)
Studies cited
17 studies from PubMed
- Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers
- Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
- The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group
- Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial
- The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial
- Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial
- Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
- Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
- Effects of ipsapirone and cannabidiol on human experimental anxiety
- A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis
- Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome
- Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
- Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex
- The efficacy of cannabidiol for seizures reduction in pharmacoresistant epilepsy: a systematic review and meta-analysis.
- Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay
- Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination
- A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms