Condition
Nocturnal Enuresis
Nocturnal enuresis is bedwetting during sleep, which happens when a child's body makes a lot of urine overnight, the bladder holds little, or sleep is too deep to notice a full bladder. Among options studied, the evidence is strongest for desmopressin, and trials found about 2.2 fewer wet nights per week than placebo. Still, only about 35% of children became completely dry, and a review also described cases of severe low blood sodium.
Sources: PMID 2220513; PMID 23619353
- Updated
- How we grade
- 54 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 2
No supplement studies yetWe haven’t found supplement studies for Nocturnal Enuresis. The medicines and peptides studied for it are listed below.
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Wet Nights (Enuresis) 2.2 fewer wet nights per week vs placebo. Children 4.5x more likely to sleep without disruption. 35% achieved complete dryness in studies. | Improves (the measure goes down) | Large effect | 33 studies | |||
Studies that measured wet nights (enuresis) | ||||||
| Sleep Quality (Enuresis) Improved sleep quality and reduced sleep disruption in children and adults with nocturnal enuresis. | Improves (the measure goes up) | Moderate effect | 33 studies | |||
Studies that measured sleep quality (enuresis) | ||||||
Key findings
- Wet Nights (Enuresis)Improves (the measure goes down)
- Sleep Quality (Enuresis)Improves (the measure goes up)
Studies cited
54 studies from PubMed
- A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?
- Lithium-induced Nephrogenic Diabetes Insipidus with Efficacy of Desmopressin in Combination with Thiazide Diuretics and Non-steroidal Anti-inflammatory Drugs: A Case Report with a Review of the Literature.
- Desmopressin, Misoprostol, nor Carboprost Affect Platelet Aggregability Following Traumatic Brain Injury and Aspirin.
- Desmopressin use in major cardiac surgery is associated with renal impairment: a retrospective single-center analysis.
- Safety and efficacy of desmopressin (DDAVP) in preventing hematoma expansion in intracranial hemorrhage associated with antiplatelet drugs use: A systematic review and metaanalysis.
- Desmopressin (DDAVP) use in patients with von Willebrand disease: A single-centre retrospective review of test response and clinical outcomes.
- Infection with SARS-CoV-2 may alter the half-life of desmopressin (DDAVP) in patients with central diabetes insipidus.
- Desmopressin Stimulates Nitric Oxide Production in Human Lung Microvascular Endothelial Cells.
- Desmopressin in canine mammary carcinoma: Comments on the importance of the administration route.
- Safety of renal biopsy bleeding prophylaxis with desmopressin.
- Effect of Desmopressin on Platelet Dysfunction During Antiplatelet Therapy: A Systematic Review.
- Desmopressin and nocturnal voiding dysfunction: Clinical evidence and safety profile in the treatment of nocturia.
- Desmopressin in non-severe haemophilia A: Test-response and clinical outcomes in a single Canadian centre review.
- Diabetes insipidus during pregnancy.
- Diabetes insipidus and pregnancy.
- The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models.
- Desmopressin to Prevent Rapid Sodium Correction in Severe Hyponatremia: A Systematic Review.
- A systematic review of the efficacy and safety of desmopressin for nocturia in adults.
- Desmopressin for reducing postoperative blood loss and transfusion requirements following cardiac surgery in adults.
- Severe signs of hyponatremia secondary to desmopressin treatment for enuresis: a systematic review.
- Efficacy and safety of desmopressin for treatment of nocturia: a systematic review and meta-analysis of double-blinded trials.
- The use of desmopressin in acquired haemophilia A: a systematic review.
- Adenotonsillectomy in patients with desmopressin responsive mild bleeding disorders: a review of the literature.
- The comparative safety of oral versus intranasal desmopressin for the treatment of children with nocturnal enuresis.
- Desmopressin 30 years in clinical use: a safety review.
- The use of desmopressin as a hemostatic agent: a concise review.
- Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations
- Desmopressin: a nightly option for nocturnal enuresis
- Desmopressin : safety considerations in patients with chronic renal disease.
- Desmopressin and other synthetic vasopressin analogues in cancer treatment.
- Use of desmopressin (DDAVP) during early pregnancy in factor VIII-deficient women.
- Desmopressin in central diabetes insipidus
- The risk of hyponatremia in older adults using desmopressin for nocturia: a systematic review and meta-analysis.
- Desmopressin (DDAVP)-induced pseudotumor cerebri.
- Desmopressin for nocturnal enuresis in children
- Desmopressin in hemophilia A and von Willebrand's disease
- Desmopressin usage in elective cardiac surgery.
- Desmopressin (DDAVP) in the treatment of bleeding disorders
- Desmopressin in the treatment of nocturnal enuresis in children: a multicenter study
- Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years
- Intranasal desmopressin-associated hyponatremia: a case report and literature review.
- The use of desmopressin (DDAVP) in hemostatic therapy
- Desmopressin side effects.
- Side effects and complications of treatment with desmopressin for enuresis.
- Desmopressin acetate in cardiac surgery: a double-blind, randomized study.
- Efficacy, safety, and dosing of desmopressin for nocturnal enuresis in Europe.
- Desmopressin for diabetes insipidus, hemostatic disorders and enuresis
- Use of desmopressin in the management of aspirin-related and intractable haemorrhage after cardiopulmonary bypass.
- Clinical experience with desmopressin: efficacy and safety in central diabetes insipidus and other conditions.
- Management of cranial diabetes insipidus with oral desmopressin (DDAVP).
- Desamino-D-arginine-vasopressin (DDAVP) in Alzheimer's disease.
- Desmopressin
- Vasopressin analog DDAVP in the treatment of diabetes insipidus
- Desmopressin (DDAVP) in diabetes insipidus.