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Desmopressin (DDAVP)

Peptide

Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analog of antidiuretic hormone (vasopressin). FDA-approved since 1978, it is used for central diabetes insipidus, nocturnal enuresis, hemophilia A, and von Willebrand disease. It has enhanced antidiuretic potency with minimal pressor effect and longer duration than native vasopressin.

Quick Answer

What it is

Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analog of antidiuretic hormone (vasopressin). FDA-approved since 1978, it is used for central diabetes insipidus, nocturnal enuresis, hemophilia A, and von Willebrand disease.

Key findings

  • Grade A: Urine Output (Diabetes Insipidus) (Central Diabetes Insipidus)
  • Grade A: Fluid Balance (Central Diabetes Insipidus)
  • Grade A: Wet Nights (Enuresis) (Nocturnal Enuresis)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Desmopressin (DDAVP)

Quick Facts: Desmopressin (DDAVP)

  • Best Evidence:Grade A
  • Conditions Studied:3
  • Research Outcomes:14
  • Grade A Findings:6
  • Grade B Findings:2
  • Key Effect:Central Diabetes Insipidus
A6
B2
C4
D2
3 conditions · 14 outcomes

Detailed Outcomes

|
A
Urine Output (Diabetes Insipidus)
First-line treatment for central diabetes insipidus. Dramatically reduces polyuria and normalizes fluid balance with intranasal or oral administration.
large↓Improves
A
Fluid Balance
Restores normal fluid homeostasis in central diabetes insipidus patients, reducing polydipsia and polyuria.
large↑Improves
A
Wet Nights (Enuresis)
2.2 fewer wet nights per week vs placebo. Children 4.5x more likely to sleep without disruption. 35% achieved complete dryness in studies.
large↓Improves
A
Sleep Quality (Enuresis)
Improved sleep quality and reduced sleep disruption in children and adults with nocturnal enuresis.
moderate↑Improves
A
Factor VIII Levels
2-4 fold increase in factor VIII coagulant activity, allowing minor surgery in mild hemophilia A without factor concentrates.
large↑Improves
A
von Willebrand Factor Levels
Up to 4-fold increase in vWF levels. Effective for von Willebrand disease Type I and some Type II variants.
large↑Improves
B
Safety/Tolerability
12 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
moderate↑Improves
B
Blood Glucose Control
7 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
small↓Improves
C
Cardiac Protection
4 human trials support this finding. Human clinical trial data available.
small↑Improves
C
Anti-Cancer Activity
4 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Kidney Function
4 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
small↑Improves
C
Reproductive Outcomes
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Pulmonary Function
2 human trials support this finding. Human clinical trial data available.
small↑Improves
D
Neuroprotection
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves

Research Citations (54)

A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?
(2025)
PMID: 40723839
Lithium-induced Nephrogenic Diabetes Insipidus with Efficacy of Desmopressin in Combination with Thiazide Diuretics and Non-steroidal Anti-inflammatory Drugs: A Case Report with a Review of the Literature.
(2024)
PMID: 37779064
Desmopressin, Misoprostol, nor Carboprost Affect Platelet Aggregability Following Traumatic Brain Injury and Aspirin.
(2024)
PMID: 38359679
Desmopressin use in major cardiac surgery is associated with renal impairment: a retrospective single-center analysis.
(2024)
PMID: 39375596
Safety and efficacy of desmopressin (DDAVP) in preventing hematoma expansion in intracranial hemorrhage associated with antiplatelet drugs use: A systematic review and metaanalysis.
(2024)
PMID: 38778788
Desmopressin (DDAVP) use in patients with von Willebrand disease: A single-centre retrospective review of test response and clinical outcomes.
(2023)
PMID: 37257847
Infection with SARS-CoV-2 may alter the half-life of desmopressin (DDAVP) in patients with central diabetes insipidus.
(2022)
PMID: 36240057
Desmopressin Stimulates Nitric Oxide Production in Human Lung Microvascular Endothelial Cells.
(2022)
PMID: 35327581
Desmopressin in canine mammary carcinoma: Comments on the importance of the administration route.
(2021)
PMID: 32700352
Safety of renal biopsy bleeding prophylaxis with desmopressin.
(2021)
PMID: 34590925