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Dr. Grey AI

Condition

Hand-Foot Syndrome

Hand-foot syndrome is a side effect of certain chemotherapy drugs that brings redness, swelling and pain to the palms of the hands and soles of the feet. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. People often ask about vitamin B6 and urea cream, but how well they work is still an open question.

Supplements studied
1
Graded outcomes
0
Trials
2
People studied
111

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Vitamin B6

Vitamin B6: outcomes studied for Hand-Foot Syndrome
GradeOutcomeEffectSizeStudiesPeopleStudies list
Hand-Foot Syndrome SymptomsImproves (the measure goes down)2 studies111 people

Studies that measured hand-foot syndrome symptoms

The Hand-Foot Syndrome (Palmar-Plantar Erythrodysesthesia) Support protocol

1 primary supplement · 3 supporting supplements

See the full protocol

Studies cited

14 studies from PubMed

  1. Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical TrialJ Caring Sci · PMID 26989667
  2. Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxinePhytomedicine · PMID 23195474
  3. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJ Womens Health Gend Based Med · PMID 10746516
  4. Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptomsJ Caring Sci · PMID 25276694
  5. [Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]Boll Soc Ital Biol Sper · PMID 6324828
  6. A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modificationsBr J Cancer · PMID 22814578
  7. Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusionInvest New Drugs · PMID 2345070
  8. The effects of vitamin B6 supplementation on premenstrual symptomsObstet Gynecol · PMID 3299182
  9. Pyridoxine (vitamin B6) therapy for premenstrual syndromeInt J Gynaecol Obstet · PMID 17187801
  10. Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trialJ R Coll Gen Pract · PMID 2558186
  11. No effect of vitamin B-6 against premenstrual tension. A controlled clinical studyActa Obstet Gynecol Scand · PMID 3914180
  12. Controlled trial of pyridoxine in the premenstrual syndromeJ Int Med Res · PMID 3891456
  13. Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exerciseN Engl J Med · PMID 7088124
  14. Effects of pyridoxine on dreaming: a preliminary studyPercept Mot Skills · PMID 11883552

Supplement stack for Hand-Foot Syndrome