Dr. Grey AI

Autoimmune Health

Research on autoimmune conditions where the immune system attacks the body's own tissues, including rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease.

Quick Answer

What it is

Research on autoimmune conditions where the immune system attacks the body's own tissues, including rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease.

Key findings

  • Grade C: Immune Function (Yeast Mannan)
  • Grade D: Immune Cell Modulation (Valine)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Autoimmune Health

  • Supplements Studied:0
  • Top Supplement:Yeast Mannan (C)
0 supps · 0 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
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C
Immune Function
Multiple animal studies across fish, mice, and poultry consistently demonstrate immune-modulatory effects of MOS, including enhanced innate immune parameters and improved immune responses to pathogen challenge. A mouse study (PMID:29723205) confirmed immune-modulatory properties of dietary yeast-derived MOS, though no human clinical trials exist.
4 studies
small↑Improves
D
Immune Function
In vitro and animal studies suggest Codonopsis polysaccharides enhance immune cell function, including stimulation of macrophage activity and cytokine production. No controlled human trials have confirmed these effects.
5 studies
small↑Improves
D
Immune Function
Animal studies demonstrate dose-dependent modulation of spleen lymphocyte function by dietary GLA. Cyclic vs continuous enteral feeding with GLA altered immune cell phospholipid fatty acid composition in rat lung and liver. Reviews highlight the importance of n-6/n-3 balance in immune regulation, autoimmunity, and the essentiality of n-6 for normal immune function.
4 studies
small↑Improves
D
Immune Function
Dendrobium polysaccharides show immunomodulatory effects in animal models, enhancing aspects of both innate and adaptive immunity. No human immunological trials exist.
3 studies
small↑Improves
D
Immune Function
In immunosuppressed mice, longan pulp polysaccharide-protein complex (100 mg/kg/day) significantly increased antibody production, splenocyte proliferation, macrophage phagocytosis, and NK cell cytotoxicity, with efficacy comparable to ganoderan. In vitro, a novel longan polysaccharide (LP4) activated macrophages via TLR2/4-mediated PI3K/AKT and MyD88/TRAF6 pathways.
2 studies
moderate↑Improves
D
Immune Cell Modulation
In vitro studies showed BCAAs influenced immune properties of microglial cells and their responsiveness to pro-inflammatory signals. A separate study found BCAAs improved mesenchymal stem cell proliferation while reducing NF-κB expression and modulating inflammatory properties. These are preclinical cell-culture findings with no human data for isolated valine.
2 studies
small↑Improves

Research Citations (70)

Comparative effects of Saccharomyces cerevisiae, mannan-oligosaccharides, and their synbiotic on growth performance, gut morphology, immune responses, and economic efficiency in broiler chickens.
(2026)
PMID: 41610607
Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia
(2025)
PMID: 39923958
Response of broiler chickens to dietary different yeast cell wall components challenged with Salmonella typhimurium.
(2025)
PMID: 40996575
Dendrobium as a new natural source of bioactive for prevention and treatment of digestive tract diseases
(2023)
PMID: 37011417
Bioactivities and mechanism of actions of Dendrobium officinale: a comprehensive review
(2022)
PMID: 36160715
Network pharmacologic analysis of Dendrobium officinale extract inhibiting the proliferation of gastric cancer cells
(2022)
PMID: 35401206
Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl3 and an irregular diet via RAS/MEK/ERK signaling pathway
(2021)
PMID: 33249246
Regulation of Skeletal Muscle Function by Amino Acids.
(2020)
PMID: 31963899
Short-Term Effects of Branched-Chain Amino Acids-Enriched Dialysis Fluid on Branched-Chain Amino Acids Plasma Level and Mass Balance: A Randomized Cross-Over Study.
(2020)
PMID: 31078402
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.
(2020)
PMID: 32200651

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