Condition
Antidepressant-Induced Sexual Dysfunction (AISD)
Antidepressant-induced sexual dysfunction is a common side effect of SSRIs and SNRIs, where extra serotonin dampens dopamine and norepinephrine pathways, lowering libido and arousal or delaying orgasm. Maca and saffron are the supplements studied most directly for it, though little research on them has been reviewed here so far. Ginkgo, L-arginine and ashwagandha have drawn interest too, but their evidence is limited, so it is early to say how well any work.
Sources: PMID 18801111; PMID 23280545
- Supplements studied
- 2
- Graded outcomes
- 0
- Trials
- 2
- People studied
- 82
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Libido | Improves (the measure goes up) | 4 studies | 37 people | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Sexual Function | Improves (the measure goes up) | 2 studies | 45 people | |||
The Antidepressant-Induced Sexual Dysfunction Support protocol
2 primary supplements · 5 supporting supplements
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Antidepressant-Induced Sexual Dysfunction (AISD). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
Fullscript collectionMen's health: evidence-graded picksOpen on Fullscript
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
Studies cited
100 studies from PubMed
- Effect of Ginkgo biloba Extract on Cognitive Function: A Systematic Review
- Efficacy and Safety of Ginkgo biloba in Mild Cognitive Impairment: A Meta-Analysis
- Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Outcomes
- Ginkgo biloba L. Historical Background and Current Applications in Medicine
- Ginkgo biloba and Brain Health: A Comprehensive Review
- Safety Profile of Ginkgo biloba Extract: Evidence from Clinical Trials
- Pharmacokinetics and Bioavailability of Ginkgo biloba Extract
- Neuroprotective Effects of Ginkgo biloba Extract: A Review
- Efficacy of Ginkgo biloba on Peripheral Arterial Disease: Meta-Analysis
- Ginkgo biloba Extract for Age-Related Macular Degeneration: A Meta-Analysis
- Ginkgo biloba Extract for Cognitive Decline and Dementia: A Cochrane Review Summary
- Ginkgo biloba for Tinnitus: A Systematic Review and Meta-Analysis
- Ginkgo biloba Special Extract EGb 761 in Dementia: A Review
- Efficacy of Ginkgo biloba in Treating Acute Ischemic Stroke: A Meta-Analysis
- Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers
- Effect of Ginkgo biloba (EGb 761) on treadmill walking time among adults with peripheral artery disease: a randomized clinical trial
- Study of the antiischemic action of EGb 761 in the treatment of peripheral arterial occlusive disease by TcPo2 determination
- 6-Month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency
- Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patients
- Does Ginkgo biloba reduce the risk of cardiovascular events
- A new ginkgo fresh plant extract increases microcirculation and radical scavenging activity in elderly patients
- Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial
- Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine
- Ginkgo biloba for antidepressant-induced sexual dysfunction
- A placebo-controlled study of extract of ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia
- The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia
- A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia
- Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba
- Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood
- Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs
- Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women
- An examination of the efficacy of Ginkgo biloba extract EGb761 on the neuropsychologic functioning of cognitively intact older adults
- Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine
- A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings
- Cognitive performance, SPECT, and blood viscosity in elderly non-demented people using Ginkgo biloba
- Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial
- Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trial
- Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study
- Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial
- Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
- Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg
- Effect of Western medicine therapy assisted by Ginkgo biloba tablet on vascular cognitive impairment of none dementia
- A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
- Ginkgo biloba for prevention of dementia: a randomized controlled trial
- Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent
- Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT)
- Ginkgo biloba does--and does not--prevent acute mountain sickness
- Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollagüe (3696 m) in northern Chile
- Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial
- EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure
- Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba
- Ginkgo biloba for tinnitus
- Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial
- Effect of Ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy
- The effect of Li 1370, extract of Ginkgo biloba, on REM sleep in humans
- Ginkgo biloba for acute ischaemic stroke
- Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
- Value of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndrome
- Influence of Ginkgo biloba on ocular blood flow
- Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma
- Ginkgo biloba extract increases ocular blood flow velocity
- A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome
- Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers
- Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers
- Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women
- Acute effects of Ginkgo biloba extract on vascular function and blood pressure
- Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double blind placebo-controlled study
- Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
- Safety and effectiveness of a traditional ginkgo fresh plant extract - results from a clinical trial
- Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) Study
- Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials
- A clinical trial of Gingkco Biloba Extract in patients with intermittent claudication
- Demonstration of the efficacy of ginkgo biloba special extract EGb 761 on intermittent claudication--a placebo-controlled, double-blind multicenter trial
- Ginkgo biloba does not improve cognitive function in MS: a randomized placebo-controlled trial
- Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids
- Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans
- A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction
- No significant effect of ginkgo biloba special extract EGb 761 in the treatment of primary Raynaud phenomenon: a randomized controlled trial
- To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phenomenon in South Korea; Korean Raynaud study (KOARA study)
- Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo
- Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial
- First preliminary results of an observation of Ginkgo Biloba treating patients with autistic disorder
- A double-blind placebo controlled trial of Ginkgo biloba added to risperidone in patients with autistic disorders
- Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial
- Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma
- The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled trials.
- Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials.
- Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient study
- Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical Study
- Use of gelatinized maca (lepidium peruvianum) in early postmenopausal women
- Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled Study
- Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content
- Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men
- Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men
- Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
- Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis.
- A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen
- Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial
- A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women
- A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction