Polygala Tenuifolia
Polygala tenuifolia is a root used in traditional Chinese medicine for its ability to improve memory and protect against cognitive ailments. Limited human evidence suggests Polygala tenuifolia cannot improve memory, but may improve spatial awareness and organization.
Quick Answer
What it is
Polygala tenuifolia is a root used in traditional Chinese medicine for its ability to improve memory and protect against cognitive ailments. Limited human evidence suggests Polygala tenuifolia cannot improve memory, but may improve spatial awareness and organization.
Key findings
- Grade C: Cognitive Decline
- Grade D: Memory
- Grade N/A: Verbal Fluency
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Polygala Tenuifolia
Quick Facts: Polygala Tenuifolia
- Best Evidence:Grade C
- Conditions Studied:2
- Research Outcomes:9
- Key Effect:Age-Associated Memory Impairment and Cognitive Decline (AAMCD)
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (2)
Related Supplements
Phosphatidylserine
3 shared conditions · 73 outcomes
Phosphatidylserine (PS) is an amino acid derivative that is fat soluble and found in high amounts in the brain, where it contributes to cognitive functioning. PS has been studied the most for cognition in adults over 50, for people with high chronic stress, and for exercise performance, but further research is needed to confirm any benefit.
Ginkgo Biloba
3 shared conditions · 173 outcomes
Ginkgo biloba is the most commonly ingested herb for brain health. While it may boost cognition in older populations, this effect is not very reliable or generalizable.
Bacopa Monnieri
3 shared conditions · 53 outcomes
Bacopa monnieri is an Ayurvedic nootropic herb traditionally used for memory and cognitive enhancement ('Medhya Rasayana'). C-grade evidence for anxiety improvement, anhedonia (in depression), and alertness. D-grade for attention and Alzheimer's symptoms (no effect). Memory benefits are more consistent but require 8-12 weeks of consistent use. Works primarily via bacosides affecting cholinergic and serotonergic systems. One of the better-studied herbal nootropics but effects are modest and slow-developing.
Vitamin B12
2 shared conditions · 18 outcomes
Vitamin B12 is an essential water-soluble vitamin that plays a role in neurological function and is important for DNA synthesis.
Piracetam
2 shared conditions · 15 outcomes
Piracetam is the parent compound of the racetam class of nootropic supplements. When supplemented, it provides a mild boost to brain function.
Fish Oil
2 shared conditions · 448 outcomes
Fish oil is a mix of mostly EPA and DHA derived from fatty fish. It reduces triglycerides, but does not seem to affect the rate of cardiovascular events. It appears to reduce the symptoms of depression and improve some painful, inflammatory conditions.
Curcumin
2 shared conditions · 502 outcomes
Curcumin is the primary bioactive substance in turmeric. It has anti-inflammatory properties and can alleviate symptoms of depression as well as improve pain and function in people with osteoarthritis.
CDP-Choline
2 shared conditions · 15 outcomes
CDP-Choline (citicoline) is a nootropic compound that provides both choline and cytidine (which converts to uridine). Used medically for stroke recovery and cognitive decline. More potent than phosphatidylcholine for brain choline delivery. Evidence is strongest for cognitive support in age-related decline and stroke rehabilitation. Also studied for cocaine addiction (small improvement). May increase phosphatidylcholine synthesis in brain. Generally well-tolerated with excellent safety profile.