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Creatinol O-Phosphate

Creatinol O-phosphate is a compound related to creatine that heart muscle cells can use in their energy metabolism. People mostly look at it for heart rhythm problems, and human trials from the late 1970s found that injected doses reduced extra ventricular beats in people with ischemic heart disease, with moderate evidence. Those studies were small, all used injections rather than oral forms, and the other heart findings rest mostly on animal or lab work.

Sources: PMID 395959; PMID 575497

Best evidence
Grade B
Conditions studied
3
Outcomes
3
Graded outcomes
0111

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

3 conditions

Cardiovascular Disease

Cardiovascular Disease: outcomes studied for Creatinol O-Phosphate
GradeOutcomeEffectSizeStudiesPeopleStudies list
Ventricular Arrhythmia Reduction (IV Administration)

Multiple human clinical trials from the late 1970s, including double-blind studies, found that intravenous COP (1-3g) reduced ventricular premature beats and showed antiarrhythmic effectiveness in patients with ischemic heart disease. All evidence is limited to IV injection; no data exists for oral administration.

Improves (the measure goes down)Moderate effect8 studies100 people

Studies that measured ventricular arrhythmia reduction (iv administration)

Acute Coronary Syndrome (ACS)

Acute Coronary Syndrome (ACS): outcomes studied for Creatinol O-Phosphate
GradeOutcomeEffectSizeStudiesPeopleStudies list
Myocardial Ischemia Protection (IV Administration)

A double-blind clinical trial found IV COP improved outcomes in patients with inadequate coronary circulation. Animal studies in rats and mice showed COP protected against isoprenaline-induced cardiac enzyme elevation and CaCl2-induced ventricular fibrillation. An in vitro NMR study in perfused Xenopus heart confirmed effects on cardiac energy metabolism. All evidence is from IV or direct perfusion, not oral dosing.

Improves (the measure goes up)Moderate effect10 studies80 people

Studies that measured myocardial ischemia protection (iv administration)

Cardiovascular Health

Cardiovascular Health: outcomes studied for Creatinol O-Phosphate
GradeOutcomeEffectSizeStudiesPeopleStudies list
Cardiac Hemodynamic Function (IV Administration)

A single preclinical study in conscious and anaesthetized dogs examined the effects of IV COP on haemodynamics and cardiac metabolism, providing early evidence of cardiovascular activity. No human replication or oral bioavailability data exists.

Improves (the measure goes up)Small effect5 studies

Studies that measured cardiac hemodynamic function (iv administration)

Key findings

  • Ventricular Arrhythmia Reduction (IV Administration)Cardiovascular DiseaseImproves (the measure goes down)
  • Myocardial Ischemia Protection (IV Administration)Acute Coronary Syndrome (ACS)Improves (the measure goes up)
  • Cardiac Hemodynamic Function (IV Administration)Cardiovascular HealthImproves (the measure goes up)

Shop the evidence-backed picks

Third-party tested Creatinol O-Phosphate products, in the forms the graded studies used where we can match them.

  • Grade B

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Studies cited

15 studies from PubMed

  1. A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain.Pharmacological Research, 1993 · PMID 8278305
  2. Double-blind evaluation of creatinol O-phosphate in chronic congestive heart insufficiencyInt J Clin Pharmacol Ther Toxicol, 1984 · PMID 6390133
  3. Antiarrhythmic effects of creatinol O-phosphateArzneimittelforschung, 1984 · PMID 6369229
  4. Creatinol O-phosphate in acute myocardial infarctionG Ital Cardiol, 1981 · PMID 7021841
  5. Antiarrhythmic effectiveness of creatinol O-phosphate in man.Arzneimittel-Forschung, 1979 · PMID 94266
  6. Pharmacological and toxicological properties of creatinol O-phosphate. A review.Arzneimittel-Forschung, 1979 · PMID 395957
  7. Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double blind clinical trial.Arzneimittel-Forschung, 1979 · PMID 395958
  8. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial.Arzneimittel-Forschung, 1979 · PMID 395959
  9. Acute clinical tolerance of creatinol O-phosphate.Arzneimittel-Forschung, 1979 · PMID 575490
  10. Protective action of creatinol O-phosphate against serum CPK activity enhanced by isoprenaline in the rat.Arzneimittel-Forschung, 1979 · PMID 575495
  11. Protective effect of creatinol O-phosphate (COP) on ventricular fibrillation and death induced by intravenous CaCl2 in mice.Arzneimittel-Forschung, 1979 · PMID 575496
  12. Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo.Arzneimittel-Forschung, 1979 · PMID 575497
  13. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction.Arzneimittel-Forschung, 1979 · PMID 575498
  14. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects.Arzneimittel-Forschung, 1979 · PMID 575499
  15. Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs.Arzneimittel-Forschung, 1978 · PMID 582673