Creatinol O-Phosphate

Creatinol O-Phosphate (COP) is a synthetic creatine analogue developed in the 1970s-80s for cardioprotection. Injected COP (1-3g IV) showed benefits for arrhythmias and protecting cardiac tissue during ischemia. However, research ceased decades ago and oral bioavailability is unknown. Sold in pre-workout supplements for supposed muscle performance benefits, but NO evidence supports oral use for exercise. The cardioprotective research was via injection only. Essentially an abandoned pharmaceutical with unclear oral effects.

Quick Answer

What it is

Key findings

Grade B: Ventricular Arrhythmia Reduction (IV Administration)
Grade C: Myocardial Ischemia Protection (IV Administration)
Grade D: Cardiac Hemodynamic Function (IV Administration)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Creatinol O-Phosphate

Quick Facts: Creatinol O-Phosphate

Best Evidence:Grade B
Conditions Studied:3
Research Outcomes:3
Grade B Findings:1
Key Effect:Cardiovascular Disease

Outcomes by grade:

3 conditions · 3 outcomes

Detailed Outcomes

Ventricular Arrhythmia Reduction (IV Administration)

Multiple human clinical trials from the late 1970s, including double-blind studies, found that intravenous COP (1-3g) reduced ventricular premature beats and showed antiarrhythmic effectiveness in patients with ischemic heart disease. All evidence is limited to IV injection; no data exists for oral administration.

100 participants

moderate↓Improves

Myocardial Ischemia Protection (IV Administration)

A double-blind clinical trial found IV COP improved outcomes in patients with inadequate coronary circulation. Animal studies in rats and mice showed COP protected against isoprenaline-induced cardiac enzyme elevation and CaCl2-induced ventricular fibrillation. An in vitro NMR study in perfused Xenopus heart confirmed effects on cardiac energy metabolism. All evidence is from IV or direct perfusion, not oral dosing.

80 participants

moderate↓Improves

Cardiac Hemodynamic Function (IV Administration)

A single preclinical study in conscious and anaesthetized dogs examined the effects of IV COP on haemodynamics and cardiac metabolism, providing early evidence of cardiovascular activity. No human replication or oral bioavailability data exists.

small↑Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BCardiovascular Disease

1 outcome · 4 studies

↓Ventricular Arrhythmia Reduction (IV Administration)Improves

CAcute Coronary Syndrome (ACS)

1 outcome · 5 studies

↓Myocardial Ischemia Protection (IV Administration)Improves

DCardiovascular Health

1 outcome · 1 study

↑Cardiac Hemodynamic Function (IV Administration)Improves

Research Citations (15)

A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain.

Pharmacological Research (1993)

PMID: 8278305

Double-blind evaluation of creatinol O-phosphate in chronic congestive heart insufficiency

Int J Clin Pharmacol Ther Toxicol (1984)

PMID: 6390133

Antiarrhythmic effects of creatinol O-phosphate

Arzneimittelforschung (1984)

PMID: 6369229

Creatinol O-phosphate in acute myocardial infarction

G Ital Cardiol (1981)

PMID: 7021841

Antiarrhythmic effectiveness of creatinol O-phosphate in man.

Arzneimittel-Forschung (1979)

PMID: 94266

Pharmacological and toxicological properties of creatinol O-phosphate. A review.

Arzneimittel-Forschung (1979)

PMID: 395957

Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double blind clinical trial.

Arzneimittel-Forschung (1979)

PMID: 395958

Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial.

Arzneimittel-Forschung (1979)

PMID: 395959

Acute clinical tolerance of creatinol O-phosphate.

Arzneimittel-Forschung (1979)

PMID: 575490

Protective action of creatinol O-phosphate against serum CPK activity enhanced by isoprenaline in the rat.

Arzneimittel-Forschung (1979)

PMID: 575495

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