Supplement

Alanylglutamine

Alanylglutamine is a compound of two amino acids, alanine and glutamine, that the body splits to supply glutamine, a fuel for immune and gut cells. People mostly look at it for exercise fatigue, and fatigue symptoms improved in a small group of 10 basketball players, though the evidence is limited. Other small studies found no clear difference in heart rate, a stress hormone in cyclists, or immune cells in people with HIV.

Updated 30 September 2026
How we grade
4 studies cited

Best evidence: Grade C
Conditions studied: 3
Outcomes: 21
Graded outcomes: 0013

Evidence by condition

Strong
Moderate
Limited
Very limited

3 conditions

Basketball performance

Basketball performance: outcomes studied for Alanylglutamine
Grade	Outcome	Effect	Size	Studies	People
	Fatigue Symptoms Small Improvement	Improves (the measure goes down)	Small effect		10 people
	Heart Rate No effect		NoneNo effect		10 people
	Power Output	Improves (the measure goes up)		1 study	10 people
Studies that measured power output L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball gameJ Int Soc Sports Nutr · PMID 22397703
	Hydration (Total Body Water)	Improves (the measure goes up)			10 people
	Reaction Time	Improves (the measure goes up)			10 people

Cycling Performance

Cycling Performance: outcomes studied for Alanylglutamine
Grade	Outcome	Effect	Size	Studies	People
	Adrenocorticotropic Hormone No effect		NoneNo effect		10 people
	Blood Lactate (Exercise)	Changes; see studies		1 study	10 people
Studies that measured blood lactate (exercise) Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr · PMID 20181080
	Aldosterone	Improves (the measure goes up)			10 people
	Anaerobic Capacity	Improves (the measure goes up)			10 people
	Blood glucose	Changes; see studies			10 people
	Cortisol	Changes; see studies			10 people
	Growth Hormone	Improves (the measure goes up)			10 people
	Heart Rate	Changes; see studies			10 people
	Interleukin 6	Changes; see studies			10 people
	Oxidative Stress Biomarkers	Changes; see studies			10 people
	Testosterone	Improves (the measure goes up)			10 people
	Vasopressin	Improves (the measure goes up)			10 people

Human Immunodeficiency Virus (HIV)

Human Immunodeficiency Virus (HIV): outcomes studied for Alanylglutamine
Grade	Outcome	Effect	Size	Studies	People
	CD4 Lymphocytes No effect		NoneNo effect		37 people
	HIV Viral Load	Improves (the measure goes up)		1 study	37 people
Studies that measured hiv viral load Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trialArq Gastroenterol · PMID 23657308
	Intestinal Permeability	Improves (the measure goes up)			37 people
	Weight	Changes; see studies			37 people

Key findings

Fatigue SymptomsBasketball performanceImproves (the measure goes down)
Heart RateBasketball performance
Adrenocorticotropic HormoneCycling Performance

Shop Alanylglutamine

Third-party tested Alanylglutamine products. The evidence above is limited, so read it before you buy.

Grade C

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Studies cited

4 studies from PubMed

Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trialArq Gastroenterol · PMID 23657308
Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr · PMID 20181080
L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball gameJ Int Soc Sports Nutr · PMID 22397703
L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat proteinNutr Res · PMID 22575040