Urticaria (Hives) Support Protocol
Primary Stack
Core supplements with strongest evidenceDeficiency linked to chronic urticaria; supports immune modulation
Supporting Studies (1)
May help modulate immune response in chronic urticaria
Supporting Studies (1)
Supporting Stack
Additional supplements for enhanced resultsNatural antihistamine properties; reduces histamine levels
Supporting Studies (1)
Mast cell stabilizer; may reduce histamine release
Supporting Studies (1)
Anti-inflammatory; may help with chronic inflammatory conditions
Supporting Studies (1)
How This Protocol Works
Simple Explanation
Urticaria (hives) causes itchy, raised, red welts on the skin. It's caused by the release of histamine and other chemicals from cells in the skin.
TYPES:
COMMON TRIGGERS:
SYMPTOMS:
SEEK EMERGENCY CARE IF:
TREATMENT:
* Vitamin D deficiency is common in chronic urticaria.
* Antihistamines remain first-line treatment.
* Identify and avoid triggers when possible.
Expected timeline: Acute urticaria usually resolves within days to weeks. Chronic urticaria may last months to years but often eventually resolves.
Clinical Perspective
Urticaria: Mast cell activation with histamine release. Acute (<6 weeks): often allergic, viral, idiopathic. Chronic (>6 weeks): chronic spontaneous urticaria (CSU) most common; autoimmune component in 30-50%. Physical urticarias: dermographism, cold, cholinergic, pressure.
Treatment: Non-sedating H1 antihistamines first-line (can up-dose 4x). Add H2 blocker, leukotriene antagonist. Refractory: omalizumab (anti-IgE) highly effective. Cyclosporine for severe. Vitamin D: multiple studies show deficiency in CSU; supplementation may improve. Supplements adjunctive; antihistamines remain primary.
* Vitamin D (B-grade): Deficiency common. Systematic review: (PMID: 28750270). 2000-4000 IU daily.
* Probiotics (C-grade): Immune modulation. Review: (PMID: 24045160). 10-20B CFU daily.
* Vitamin C (C-grade): Antihistamine. Review: (PMID: 23440782). 1000-2000mg daily.
* Quercetin (C-grade): Mast cell stabilizer. Review: (PMID: 27187333). 500-1000mg daily.
* Omega-3 (C-grade): Anti-inflammatory. Review: (PMID: 27840029). 2-3g EPA+DHA daily.
Protocol notes: Acute: identify trigger if possible; anaphylaxis protocol if severe. Chronic: workup limited unless features suggest underlying cause. Antihistamines: up-dose before adding other agents. Omalizumab: very effective for refractory CSU. Thyroid: check; autoimmune thyroid associated. Angioedema: if with urticaria, usually mast cell-mediated; if without, consider ACEi-related or hereditary. Autoimmune screen if features suggest. Quality of life: significantly impacted; assess and support.