Protocol · Dermatological
Rosacea Protocol
Zinc and Omega-3 Fatty Acids are the core of this stack, with 2 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Rosacea.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
4 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Zinc | Amount listed: 30 mg daily | Reduces inflammatory cytokines and supports skin barrier repair through metalloproteinase inhibition
| Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2,000 mg EPA/DHA daily | Reduces inflammation via EPA/DHA competition with pro-inflammatory arachidonic acid pathways | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Probiotics (Lactobacillus) | Amount listed: 10 billion CFU daily | Modulates gut-skin axis, reducing systemic inflammation that triggers facial flushing | Not graded yet | ||
| Niacinamide (Vitamin B3) | Amount listed: 500 mg daily (or topical 4%) | Strengthens skin barrier function and reduces transepidermal water loss | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Rosacea involves chronic inflammation of facial blood vessels and skin, often connected to gut health and immune dysregulation. This protocol targets the gut-skin axis and inflammatory pathways.
- Zinc acts as the foundation by directly reducing skin inflammation and inhibiting enzymes that break down collagen. Studies show 30mg daily can reduce papules and pustules within 3 months.
- Omega-3s reduce the production of inflammatory prostaglandins that cause facial redness and flushing.
- Probiotics address the gut-skin connection—research shows rosacea patients have higher rates of SIBO (small intestinal bacterial overgrowth), and restoring gut balance can reduce flares.
- Niacinamide strengthens the skin barrier, which is often compromised in rosacea, reducing sensitivity to triggers.
Expected timeline: Reduced flushing frequency within 4-6 weeks; papule/pustule improvement over 8-12 weeks. Best results when combined with trigger avoidance (alcohol, spicy foods, extreme temperatures).