Protocol · Oncology
Prostate Cancer (Prevention & Support) Protocol
Lycopene and Green Tea Extract (EGCG) are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Prostate Cancer (Prevention & Support).
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Lycopene | Amount listed: 15–30 mg daily | Carotenoid that accumulates in prostate tissue; inhibits androgen receptor signaling and cell proliferation
| Grade C for Cancer Markers1,500 people | |
| Green Tea Extract (EGCG) | Amount listed: 400–800 mg EGCG daily | Polyphenols inhibit PSA and androgen receptor activity; promote apoptosis in prostate cells | Not graded yet | |
| Supporting stackListed as additions to the core | ||||
| Pomegranate Extract | Amount listed: 500–1,000 mg daily (or 8oz juice) | Punicalagins inhibit prostate cancer cell growth and extend PSA doubling time | Not graded yet | |
| Vitamin D3 | Amount listed: 2,000–4,000 IU daily | VDR activation promotes differentiation and inhibits proliferation in prostate cells | Not graded yet | |
| Selenium | Amount listed: 200 mcg daily (selenomethionine) | Selenoproteins have antioxidant effects; supports DNA repair mechanisms | Not graded yet | |
| Modified Citrus Pectin | Amount listed: 15 g daily | Blocks galectin-3, potentially inhibiting metastasis and tumor cell aggregation | Not graded yet | |
How this protocol works
In plain language
Prostate cancer is influenced by androgens, oxidative stress, and inflammation. These supplements target multiple pathways involved in prostate cancer prevention and progression.
- Lycopene (from tomatoes) concentrates in prostate tissue and has been consistently associated with reduced prostate cancer risk. Meta-analyses show a 10-20% risk reduction with higher intake.
- Green tea EGCG inhibits prostate cancer cell growth and can slow PSA rise in men with existing cancer. One study showed 90% risk reduction in high-risk men taking green tea catechins.
- Pomegranate has shown promise in extending PSA doubling time—the time it takes for PSA to double, a marker of cancer progression—by 2-4 times in some studies.
- Vitamin D deficiency is associated with more aggressive prostate cancer. The vitamin D receptor is expressed in prostate tissue and regulates cell growth.
- Selenium supports antioxidant selenoproteins, though the SELECT trial showed no benefit (possibly due to population already selenium-sufficient).
Important: These supplements are supportive, not replacements for standard medical treatment. Always work with your oncologist.
Expected timeline: PSA stabilization may be seen over 6-12 months. Prevention benefits require long-term use.