Protocol · Cancer Support
Myeloid Malignancies Supportive Care Protocol
Vitamin D and Omega-3 Fatty Acids are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Myeloid Malignancies Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (monitor levels; target 40–60 ng/mL) | Deficiency common in blood cancers; may support immune function and treatment response; promotes differentiation | Not graded yet | |
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory; may support treatment response and reduce inflammation | Not graded yet | |
| Supporting stackListed as additions to the core | ||||
| Vitamin C | Amount listed: 500–1,000 mg daily oral (IV high-dose only in clinical trials) | Supports immune function; high-dose IV studied in AML (TET2 mutations); oral supports general health | Not graded yet | |
| Zinc | Amount listed: 15–30 mg daily | Supports immune function; often depleted in cancer patients; important for wound healing | Not graded yet | |
| Probiotics | Amount listed: 10–20 billion CFU daily (specific strains for neutropenic patients) | Supports gut health during treatment; may reduce infections; helps with treatment side effects | Not graded yet | |
| Glutamine | Amount listed: 10–30 g daily in divided doses during treatment | May reduce mucositis and support gut barrier during chemotherapy | Not graded yet | |
| Iron | Amount listed: As directed by hematologist based on iron studies | For iron deficiency anemia (not iron overload); must monitor iron status carefully | Not graded yet | |
| Curcumin | Amount listed: 500–1,000 mg daily (enhanced absorption formulation) | Anti-inflammatory; studied for potential anti-leukemic effects; may enhance chemotherapy | Not graded yet | |
| Green Tea Extract (EGCG) | Amount listed: 400–800 mg EGCG daily (or 4–6 cups green tea) | Studied for anti-leukemic properties; may support treatment in some contexts | Not graded yet | |
How this protocol works
In plain language
Myeloid malignancies are blood cancers that arise from myeloid cells in the bone marrow. They include:
- Acute Myeloid Leukemia (AML): Rapidly progressing leukemia requiring urgent treatment
- Myelodysplastic Syndromes (MDS): "Pre-leukemia" conditions with abnormal blood cell production
- Myeloproliferative Neoplasms (MPNs): Including polycythemia vera, essential thrombocythemia, myelofibrosis
- Chronic Myeloid Leukemia (CML): Slower-progressing leukemia (often treated with targeted therapy)
CRITICAL: These are serious cancers requiring expert hematologist/oncologist care. Treatment varies by type and may include chemotherapy, targeted therapy, hypomethylating agents, stem cell transplant, or supportive care. These supplements may support overall health during treatment but are NOT treatments for cancer. ALWAYS discuss supplements with your oncology team - some may interact with chemotherapy or other treatments.
IMPORTANT CONSIDERATIONS:
- Iron: Many patients become iron-overloaded from transfusions - do NOT supplement iron without specific direction from your hematologist
- Antioxidants: Theoretical concern about reducing chemotherapy effectiveness - discuss timing with oncology team
- Neutropenia: When white blood cells are low, infection risk is high - some probiotics may not be safe
- Bleeding risk: Some supplements affect platelets - important when platelet counts are low
Vitamin D* deficiency is common and associated with worse outcomes. Supplementation may support treatment response.
Omega-3 Fatty Acids* have anti-inflammatory effects and may support overall health.
Zinc* supports immune function and wound healing.
Glutamine* may help reduce chemotherapy-related mouth sores (mucositis).
Probiotics* may support gut health but discuss with your team regarding neutropenic precautions.
Expected outcomes: Supplements provide supportive care during treatment. Work closely with your oncology team for appropriate timing and dosing.