Protocol · Cardiovascular Health
Ischemic Heart Disease Supportive Care Protocol
Omega-3 Fatty Acids and Coenzyme Q10 are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Ischemic Heart Disease Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 1 graded · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA+DHA daily (icosapent ethyl 4 g for high TG) | Reduces triglycerides; anti-inflammatory; may reduce cardiovascular events | Not graded yet | ||
| Coenzyme Q10 | Amount listed: 100–300 mg daily | Supports mitochondrial function; statin-depleted; may improve heart function
| Grade C for Blood Flow2 studies · 33 people | ||
| Supporting stackListed as additions to the core | |||||
| Magnesium | Amount listed: 300–400 mg daily | Supports cardiac rhythm; deficiency common; may reduce arrhythmias | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily | Deficiency associated with cardiovascular risk; may affect endothelial function | Not graded yet | ||
| L-Carnitine | Amount listed: 2–3 g daily | Supports fatty acid metabolism; may improve cardiac function post-MI | Not graded yet | ||
Confirmed studies for L-Carnitine (titles as PubMed lists them) | |||||
| B Vitamins (B6, B12, Folate) | Amount listed: B6 25 mg, B12 500 mcg, Folate 800 mcg daily | Lower homocysteine; mixed evidence for cardiovascular outcomes | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Ischemic Heart Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
How this protocol works
In plain language
Ischemic heart disease (IHD), also called coronary artery disease (CAD), occurs when the heart's blood supply is reduced due to narrowing or blockage of the coronary arteries. It is the leading cause of death worldwide.
HOW IT DEVELOPS:
- Atherosclerosis (plaque buildup) narrows arteries
- Less blood reaches heart muscle
- Can cause stable angina (chest pain with exertion)
- Plaque rupture causes heart attack (MI)
SYMPTOMS:
- Angina (chest pain/pressure, often with exertion)
- Shortness of breath
- Fatigue
- Heart attack: severe chest pain, sweating, nausea
- Some have no symptoms ("silent ischemia")
CRITICAL: IHD requires comprehensive medical management. This protocol is SUPPORTIVE ONLY.
GUIDELINE-DIRECTED THERAPY:
- Aspirin: Antiplatelet (unless contraindicated)
- Statins: LDL lowering (regardless of baseline)
- ACE inhibitors/ARBs: If hypertension, diabetes, or reduced EF
- Beta-blockers: After MI, for angina
- Revascularization: PCI or CABG when indicated
LIFESTYLE MODIFICATIONS (MOST IMPORTANT):
- Smoking cessation (single most important)
- Mediterranean diet
- Regular exercise (150+ min/week moderate)
- Weight management
- Blood pressure control (<130/80)
- Diabetes control (A1c <7%)
- Stress management
Omega-3s* (especially icosapent ethyl) have cardiovascular benefits.
CoQ10* supports energy production in heart muscle.
Magnesium* supports cardiac rhythm.
Expected timeline: Lifestyle changes and medications reduce cardiovascular risk over months to years. Supplements provide additional modest support.