Protocol · Endocrine
Hypothyroidism (Thyroid Support) Protocol
Selenium and Zinc are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Hypothyroidism (Thyroid Support).
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 1 graded · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Selenium | Amount listed: 200 mcg daily (selenomethionine) | Essential for deiodinase enzymes (T4→T3 conversion) and thyroid peroxidase function | Not graded yet | ||
Confirmed studies for Selenium (titles as PubMed lists them) | |||||
| Zinc | Amount listed: 25–30 mg daily | Cofactor for thyroid hormone synthesis and TSH function; deficiency impairs conversion | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Vitamin D3 | Amount listed: 2,000–4,000 IU daily (target 40–60 ng/mL) | Deficiency associated with autoimmune thyroid disease; supports immune regulation | Not graded yet | ||
| Iron (if deficient) | Amount listed: If ferritin <50: 25–50 mg elemental iron | Required for thyroid peroxidase enzyme; deficiency impairs T4 synthesis | Not graded yet | ||
| Iodine (if deficient) | Amount listed: 150–300 mcg daily (only if urinary iodine low) | Essential component of thyroid hormones; deficiency causes hypothyroidism | Not graded yet | ||
| Ashwagandha | Amount listed: 600 mg daily | May support thyroid function through HPT axis modulation; shown to increase T4 in subclinical hypothyroidism
| Grade C for Serum T350 people | ||
Shop this protocol
Support alongside medical care. These supplements are not a treatment for Hypothyroidism (Thyroid Support). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
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How this protocol works
In plain language
Hypothyroidism means your thyroid gland doesn't produce enough thyroid hormones. While levothyroxine is usually needed, these supplements address nutrient deficiencies that impair thyroid function and hormone conversion.
- Selenium is critical for thyroid health. It's required for the enzymes that convert T4 (inactive) to T3 (active). It also reduces thyroid antibodies in Hashimoto's disease by 40-50% in some studies.
- Zinc is another mineral needed for thyroid hormone production and for TSH to work properly. Zinc deficiency impairs T4 to T3 conversion.
- Vitamin D deficiency is very common in autoimmune thyroid disease. Adequate vitamin D supports immune regulation and may reduce antibody levels.
- Iron is needed for thyroid peroxidase, the enzyme that makes thyroid hormone. Low ferritin impairs thyroid function even before anemia develops.
- Iodine is the raw material for thyroid hormones. However, only supplement if you're actually deficient—excess iodine can worsen Hashimoto's.
- Ashwagandha has shown promise for subclinical hypothyroidism, with studies showing increased T4 levels.
Critical note: These supplements support thyroid function but don't replace thyroid medication if you need it. Always work with your doctor and monitor thyroid labs.
Expected timeline: Nutrient repletion takes 2-3 months. TSH and antibody changes may take 3-6 months to manifest.