Protocol · Gastrointestinal
Gastroesophageal Reflux Disease (GERD) Protocol
Melatonin and Deglycyrrhizinated Licorice (DGL) are the core of this stack, with 3 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Gastroesophageal Reflux Disease (GERD).
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
5 supplements · 1 graded · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Melatonin | Amount listed: 3–6 mg at bedtime | Reduces gastric acid secretion and strengthens lower esophageal sphincter pressure
| Grade C for Gastrin60 people | ||
Confirmed studies for Melatonin (titles as PubMed lists them) | |||||
| Deglycyrrhizinated Licorice (DGL) | Amount listed: 380–760 mg chewed before meals | Increases mucus production and promotes mucosal healing without mineralocorticoid effects | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Zinc Carnosine | Amount listed: 75 mg twice daily | Promotes mucosal healing and reduces oxidative damage to esophageal tissue | Not graded yet | ||
| D-Limonene | Amount listed: 1,000 mg every other day for 20 days | Citrus extract that coats esophagus and may promote normal peristalsis | Not graded yet | ||
| Slippery Elm | Amount listed: 400–500 mg before meals | Demulcent that coats and soothes irritated esophageal and gastric mucosa | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
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How this protocol works
In plain language
GERD occurs when stomach acid repeatedly flows back into the esophagus, causing heartburn and potentially damaging the esophageal lining. While PPIs are often used, these natural approaches can help manage symptoms and support healing.
- Melatonin has surprising benefits for GERD. It's produced in the gut in amounts 400x higher than the brain, where it inhibits acid secretion and strengthens the lower esophageal sphincter. Studies show it can be as effective as omeprazole for some patients.
- DGL (deglycyrrhizinated licorice) increases the protective mucus layer in the stomach and esophagus. The deglycyrrhizinated form removes compounds that can raise blood pressure. Chew before meals for best effect.
- Zinc carnosine is a compound of zinc and L-carnosine that concentrates in damaged mucosa and promotes healing. It's used in Japan for gastric ulcers.
- D-Limonene is a citrus extract that appears to coat the esophagus protectively. Studies show relief within 2 weeks for many users.
- Slippery elm is a traditional demulcent that coats and soothes irritated tissue.
Important lifestyle factors: Avoid eating 3 hours before bed, elevate head of bed, avoid trigger foods, maintain healthy weight.
Expected timeline: Symptom relief may begin within 1-2 weeks. Full mucosal healing takes 8-12 weeks.