Protocol · Immune
Food Allergy Protocol
Probiotics (Lactobacillus rhamnosus GG) is the core of this stack, with 3 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Food Allergy.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
4 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Probiotics (Lactobacillus rhamnosus GG) | Amount listed: 10–20 billion CFU daily | Modulates immune tolerance via Treg cell induction and reduces intestinal permeability
| Grade D for Allergic Disease Risk399 people | |
| Supporting stackListed as additions to the core | ||||
| Vitamin D3 | Amount listed: 2,000–4,000 IU daily | Promotes immune tolerance and Treg development; deficiency linked to food allergy risk | Not graded yet | |
| Quercetin | Amount listed: 500 mg twice daily | Stabilizes mast cells, reducing histamine release during allergic reactions | Not graded yet | |
| Omega-3 Fatty Acids | Amount listed: 1–2 g EPA/DHA daily | Reduces inflammatory response and may promote oral tolerance development | Not graded yet | |
How this protocol works
In plain language
Food allergies involve the immune system mistakenly attacking harmless food proteins. These supplements support immune tolerance—the process by which the body learns to accept foods as safe.
- Lactobacillus rhamnosus GG is the most studied probiotic for food allergies. It helps develop regulatory T-cells (Tregs) that suppress allergic responses. When combined with oral immunotherapy (gradual exposure to allergens), it significantly improves outcomes.
- Vitamin D plays a crucial role in immune regulation. Children with vitamin D deficiency have higher rates of food allergies. Adequate D levels support the development of tolerance.
- Quercetin is a natural mast cell stabilizer—it helps prevent the release of histamine that causes allergic symptoms.
- Omega-3s shift the immune response away from allergic (Th2) pathways.
Important: These supplements do NOT replace allergen avoidance or treat anaphylaxis. They support immune tolerance development, often alongside medical treatments like oral immunotherapy (OIT).
Expected timeline: Immune modulation is gradual—expect 3-6 months for measurable changes in tolerance.