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Gonadorelin (Factrel)

Peptide

Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. FDA-approved as diagnostic agent for evaluating pituitary gonadotrope function. Also used therapeutically for hypogonadotropic hypogonadism via pulsatile pump. In males with HH, pulsatile GnRH achieves spermatogenesis in 85% (58/68 patients). Earlier spermatogenesis vs gonadotropin therapy (6 vs 14 months, p=0.01).

Quick Answer

What it is

Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. FDA-approved as diagnostic agent for evaluating pituitary gonadotrope function.

Key findings

  • Grade A: Diagnostic Accuracy (Hypogonadotropic Hypogonadism)
  • Grade A: Spermatogenesis Induction (Hypogonadotropic Hypogonadism)
  • Grade A: Testicular Growth (Hypogonadotropic Hypogonadism)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Gonadorelin (Factrel)

Quick Facts: Gonadorelin (Factrel)

  • Best Evidence:Grade A
  • Conditions Studied:1
  • Research Outcomes:10
  • Grade A Findings:4
  • Key Effect:Hypogonadotropic Hypogonadism
A4
B0
C5
D1
1 conditions · 10 outcomes

Detailed Outcomes

A
Diagnostic Accuracy
GnRH stimulation test evaluates HPG axis. Measures LH/FSH response to bolus. Cannot distinguish CDP from IHH prepubertally, but useful post-pubertally.
moderate↑Improves
A
Spermatogenesis Induction
Pulsatile GnRH achieves spermatogenesis in 85% (58/68) of HH males. Median time 6 months with pump vs 14 months with gonadotropin therapy (p=0.01).
large↑Improves
A
Testicular Growth
100% of HH males treated with pulsatile GnRH achieve testicular growth and virilization. Physiological approach preserving fertility.
large↑Improves
A
Puberty Induction
Pulsatile GnRH induces physiological puberty in HH. Advantages over testosterone: stimulates testicular growth and fertility while achieving virilization.
large↑Improves
C
Reproductive Outcomes
21 preclinical studies support this finding. Primarily preclinical evidence.
moderate↑Improves
C
Immune Function
5 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Hair Growth
4 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Anti-Cancer Activity
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Hormone Levels
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Safety/Tolerability
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves

Research Citations (36)

Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum).
(2025)
PMID: 40645558
A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates.
(2022)
PMID: 35028691
The safety of neoadjuvant hormonal treatment in infants with cryptorchidism.
(2022)
PMID: 35691791
Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism
(2020)
PMID: 32445446
Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty
(2020)
PMID: 32883101
The Pulsatile Gonadorelin Pump Induces Earlier Spermatogenesis Than Cyclical Gonadotropin Therapy in Congenital Hypogonadotropic Hypogonadism Men
(2019)
PMID: 30764685
Impact of phase of the estrous cycle and season on LH surge profile and fertility in dairy cows treated with different GnRH analogs (gonadorelin vs. buserelin).
(2017)
PMID: 28215676
Role of Gonadotropin-releasing Hormone Stimulation Test in Diagnosing Gonadotropin Deficiency in Both Males and Females with Delayed Puberty
(2015)
PMID: 26365959
Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle.
(2015)
PMID: 25890780
Effect of different gonadorelin (GnRH) products used for the first or resynchronized timed artificial insemination on pregnancy rates in postpartum dairy cows.
(2015)
PMID: 25979657