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Condition

Hypogonadotropic Hypogonadism

Hypogonadotropic hypogonadism is a condition in which the pituitary gland releases too little LH and FSH, so the testes or ovaries make too little sex hormone. Research has focused on gonadorelin, a diagnostic test rather than a supplement, and the evidence is strong that it shows how the pituitary responds by measuring LH and FSH. Before puberty it could not separate this condition from constitutionally delayed puberty, but afterward it was useful.

Sources: PMID 15554892

Supplements studied
0
Medicines and peptides
1
Graded outcomes
4
No supplement studies yetWe haven’t found supplement studies for Hypogonadotropic Hypogonadism. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

Gonadorelin (Factrel)

Gonadorelin (Factrel): outcomes studied for Hypogonadotropic Hypogonadism
GradeOutcomeEffectSizeStudiesPeopleStudies list
Puberty Induction

Pulsatile GnRH induces physiological puberty in HH. Advantages over testosterone: stimulates testicular growth and fertility while achieving virilization.

Improves (the measure goes up)Large effect91 studies

Studies that measured puberty induction

and 88 more on the Gonadorelin (Factrel) page

Spermatogenesis Induction

Pulsatile GnRH achieves spermatogenesis in 85% (58/68) of HH males. Median time 6 months with pump vs 14 months with gonadotropin therapy (p=0.01).

Improves (the measure goes up)Large effect88 studies

Studies that measured spermatogenesis induction

and 85 more on the Gonadorelin (Factrel) page

Diagnostic Accuracy

GnRH stimulation test evaluates HPG axis. Measures LH/FSH response to bolus. Cannot distinguish CDP from IHH prepubertally, but useful post-pubertally.

Improves (the measure goes up)Moderate effect87 studies

Studies that measured diagnostic accuracy

and 84 more on the Gonadorelin (Factrel) page

Testicular Growth

100% of HH males treated with pulsatile GnRH achieve testicular growth and virilization. Physiological approach preserving fertility.

Improves (the measure goes up)Large effect87 studies

Studies that measured testicular growth

and 84 more on the Gonadorelin (Factrel) page

Key findings

  • Puberty InductionGonadorelin (Factrel)Improves (the measure goes up)
  • Spermatogenesis InductionGonadorelin (Factrel)Improves (the measure goes up)
  • Diagnostic AccuracyGonadorelin (Factrel)Improves (the measure goes up)

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Hypogonadotropic Hypogonadism. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

Fullscript collectionMen's health: evidence-graded picksOpen on Fullscript

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Studies cited

36 studies from PubMed

  1. Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum).Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2025 · PMID 40645558
  2. A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates.Analytical and bioanalytical chemistry, 2022 · PMID 35028691
  3. The safety of neoadjuvant hormonal treatment in infants with cryptorchidism.Journal of pediatric urology, 2022 · PMID 35691791
  4. Gonadotropin Treatment for the Male Hypogonadotropic HypogonadismJ Clin Med, 2020 · PMID 32445446
  5. Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious pubertyAnn Transl Med, 2020 · PMID 32883101
  6. The Pulsatile Gonadorelin Pump Induces Earlier Spermatogenesis Than Cyclical Gonadotropin Therapy in Congenital Hypogonadotropic Hypogonadism MenAm J Mens Health, 2019 · PMID 30764685
  7. Impact of phase of the estrous cycle and season on LH surge profile and fertility in dairy cows treated with different GnRH analogs (gonadorelin vs. buserelin).Theriogenology, 2017 · PMID 28215676
  8. Role of Gonadotropin-releasing Hormone Stimulation Test in Diagnosing Gonadotropin Deficiency in Both Males and Females with Delayed PubertyJ Pediatr Endocrinol Metab, 2015 · PMID 26365959
  9. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle.Theriogenology, 2015 · PMID 25890780
  10. Effect of different gonadorelin (GnRH) products used for the first or resynchronized timed artificial insemination on pregnancy rates in postpartum dairy cows.Theriogenology, 2015 · PMID 25979657
  11. Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells.Cancer prevention research (Philadelphia, Pa.), 2014 · PMID 24431404
  12. [Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2014 · PMID 25131486
  13. Comparison of gonadorelin products in lactating dairy cows: efficacy based on induction of ovulation of an accessory follicle and circulating luteinizing hormone profiles.Theriogenology, 2009 · PMID 19394072
  14. [Side effects of treatment with the long-acting gonadorelin agonist triptorelin in a case of paraphilia].Tijdschrift voor psychiatrie, 2007 · PMID 17290340
  15. [Ovulation inducing drugs].Journal de gynecologie, obstetrique et biologie de la reproduction, 2005 · PMID 16108118
  16. The effect of different doses of gonadorelin on ovarian follicle dynamics in river buffalo (Bubalus bubalis).Theriogenology, 2004 · PMID 15325555
  17. The effects of 3 gonadorelin products on luteinizing hormone release, ovulation, and follicular wave emergence in cattle.The Canadian veterinary journal = La revue veterinaire canadienne, 2003 · PMID 12650040
  18. If gonadotropin-releasing hormone plus growth hormone (GH) really improves growth outcomes in short non-GH-deficient children, then what?The Journal of clinical endocrinology and metabolism, 2001 · PMID 11443152
  19. [Research progress in immune regulation of gonadorelin].Sheng li ke xue jin zhan [Progress in physiology], 2000 · PMID 12545741
  20. Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine.Drug development and industrial pharmacy, 1999 · PMID 10071824
  21. Induction of spermatogenesis with pulsatile gonadotropin-releasing hormone in men with hypogonadotropic hypogonadismEur J Endocrinol, 1998 · PMID 3128028
  22. Response to gonadotrophin-releasing hormone by the intact male dog: serum testosterone, luteinizing hormone and follicle-stimulating hormone.Journal of reproduction and fertility. Supplement, 1993 · PMID 8229946
  23. Clinical applications of gonadotropin releasing hormone analoguesAnnu Rev Med, 1991 · PMID 1954393
  24. GnRH analogues in reproductive medicine.The Medical journal of Australia, 1991 · PMID 2056937
  25. Gonadorelin for induction of ovulation.The Medical letter on drugs and therapeutics, 1990 · PMID 2196417
  26. [Treatment of cancer of the prostate. Role of gonadorelin analogs].Presse medicale (Paris, France : 1983), 1989 · PMID 2524792
  27. Immunoglobulin-mediated hypersensitivity in response to long-term treatment with gonadorelin hydrochloride (Factrel) in a female patient.American journal of obstetrics and gynecology, 1989 · PMID 2653043
  28. Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism--diagnostic and therapeutic aspectsHorm Res, 1988 · PMID 15554892
  29. The GnRH test in the diagnosis of hypogonadotropic hypogonadismJ Clin Endocrinol Metab, 1987 · PMID 2904747
  30. Pulsatile gonadotropin-releasing hormone therapy in male patients with hypogonadotropic hypogonadismJ Clin Endocrinol Metab, 1986 · PMID 3097232
  31. The use of pulsatile gonadotropin-releasing hormone (GnRH) for the induction of puberty and fertility in patients with GnRH deficiencyEndocr Rev, 1986 · PMID 6326252
  32. Ovulation induction with pulsatile intravenous GnRH.The Journal of reproductive medicine, 1985 · PMID 3908673
  33. [Treatment of advanced prostatic cancer with a gonadorelin agonist, dTrp6 LHRH. 41 cases].Presse medicale (Paris, France : 1983), 1985 · PMID 2934695
  34. Long-term pulsatile LHRH treatment in male patients with hypogonadotropic hypogonadismFertil Steril, 1982 · PMID 2106091
  35. The International Reference Preparation of Gonadorelin for Bioassay: a comparison with different preparations of synthetic luteinizing hormone releasing hormone using physicochemical methods of analysis, different bioassays and immunoassay.The Journal of endocrinology, 1982 · PMID 6752326
  36. Induction of puberty with pulsatile gonadotropin-releasing hormoneN Engl J Med, 1980 · PMID 6419547