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Dr. Grey AI

Condition

Polymorphous Light Eruption

Polymorphous light eruption, often called sun allergy, is a common condition in which the skin develops an itchy rash of red bumps, blisters, or patches hours to days after sun exposure, usually because skin hasn't adjusted to UV light after winter. Among supplements, beta-carotene, vitamin D, nicotinamide, and Polypodium leucotomos have drawn the most interest, but little research on them has been reviewed here so far. Because no trial findings are available to report, it's too early to say how well any of them work for this rash.

Supplements studied
1
Graded outcomes
0
Trials
1
People studied
30

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Phlebodium aureum: outcomes studied for Polymorphous Light Eruption
GradeOutcomeEffectSizeStudiesPeopleStudies list
Polymorphic Light EruptionsImproves (the measure goes up)3 studies30 people

The Polymorphous Light Eruption (Sun Allergy) Supportive Care protocol

2 primary supplements · 6 supporting supplements

  • Beta-Carotene25–50 mg (40,000–80,000 IU) daily, starting 4–6 weeks before sun exposure
  • Vitamin D2,000–4,000 IU daily

See the full protocol

Shop the evidence-backed picks

Fullscript collectionSkin: evidence-graded picksOpen on Fullscript

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Studies cited

7 studies from PubMed

  1. Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatosesG Ital Dermatol Venereol · PMID 21505393
  2. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamicsMethods Find Exp Clin Pharmacol · PMID 11196347
  3. Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled studyJ Eur Acad Dermatol Venereol · PMID 17659004
  4. Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatosesPhotodermatol Photoimmunol Photomed · PMID 17254039
  5. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skinJ Am Acad Dermatol · PMID 15583582
  6. A new agent (hydrophilic fraction of polypodium leucotomos) for management of psoriasisInt J Dermatol · PMID 4609374
  7. Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruptionJ Am Acad Dermatol · PMID 21696853