Condition
Narcolepsy
Narcolepsy is a long-term neurological condition in which the brain struggles to control sleep and wake, causing heavy daytime sleepiness and sudden sleep attacks. Vitamin D and iron get the most attention, since low vitamin D is common in narcolepsy and iron influences dopamine, yet the evidence for both is limited. One very small study of 10 people found attention improved with L-tyrosine, so firm conclusions are not possible yet.
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 10
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Attention Small Improvement | Improves (the measure goes up) | Small effect | 10 people | |||
| Narcolepsy Symptoms | Improves (the measure goes down) | 1 study | 10 people | |||
Studies that measured narcolepsy symptoms | ||||||
| Sleep Latency | Improves (the measure goes down) | 10 people | ||||
Key findings
- AttentionImproves (the measure goes up)
The Narcolepsy Supportive Care protocol
2 primary supplements · 5 supporting supplements
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Narcolepsy. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
25 studies from PubMed
- Effects of L-tyrosine and carbohydrate ingestion on endurance exercise performance
- L-tyrosine ameliorates some effects of lower body negative pressure stress
- Oral l-tyrosine supplementation augments the vasoconstriction response to whole-body cooling in older adults
- Oral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults
- Dietary tyrosine benefits cognitive and psychomotor performance during body cooling
- Effect of tyrosine on cognitive function and blood pressure under stress
- Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging
- Tyrosine reverses a cold-induced working memory deficit in humans
- Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course
- The effects of tyrosine on cognitive performance during extended wakefulness
- Effect of tyrosine ingestion on cognitive and physical performance utilising an intermittent soccer performance test (iSPT) in a warm environment
- No Influence of Low-, Medium-, or High-Dose Tyrosine on Exercise in a Warm Environment
- Failure of oral tyrosine supplementation to improve exercise performance in the heat
- Oral tyrosine supplementation improves exercise capacity in the heat
- Ingestion of tyrosine: effects on endurance, muscle strength, and anaerobic performance
- Effects of tyrosine and tryptophan ingestion on plasma catecholamine and 3,4-dihydroxyphenylacetic acid concentrations
- The influence of oral tyrosine and tryptophan feeding on plasma catecholamines in man
- Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans
- The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress
- Effects of Tyrosine on Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
- L-tyrosine pharmacotherapy of schizophrenia: preliminary data
- Eating to stop: tyrosine supplementation enhances inhibitory control but not response execution
- Treatment of narcolepsy with L-tyrosine: double-blind placebo-controlled trial
- Chronic dietary tyrosine supplements do not affect mild essential hypertension
- Tyrosine for depression: a double-blind trial