Condition
Kashin-Beck Disease (KBD)
Kashin-Beck disease is a long-lasting bone and joint disorder found in parts of China, Siberia, and North Korea, in which cartilage breaks down and damages bone, causing joint pain, stiffness, and shortened fingers and limbs in children. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Selenium deficiency is a major contributing factor, alongside possible grain mycotoxins and low iodine.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 2
- People studied
- 434
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Kashin-Beck Disease Symptoms | Improves (the measure goes down) | 2 studies | 434 people | |||
The Kashin-Beck Disease Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Selenium100–200 mcg daily for prevention; may need higher during treatment phase
- Glucosamine Sulfate1,500 mg daily
Studies cited
21 studies from PubMed
- Glucosamine therapy for treating osteoarthritis
- Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial
- Comparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind study
- Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
- Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee
- Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis
- Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial
- Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial
- Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator
- Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study
- A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee
- Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee
- Glucosamine sulfate in osteoarthritis of the knee
- Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial
- No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study
- Evaluation of Glucosamine sulfate and Ibuprofen effects in patients with temporomandibular joint osteoarthritis symptom.
- Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.
- Kashin-Beck disease in Sichuan, China: report of a pilot open therapeutic trial
- Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study
- Glucosamine administration in athletes: effects on recovery of acute knee injury
- Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players