Condition
Hangover
A hangover is the rough morning after heavy drinking, driven by alcohol and its toxic byproduct acetaldehyde, along with dehydration, lost electrolytes, poor sleep and an irritated stomach. Among supplements, dihydromyricetin, electrolytes and ginger have the strongest support, each rated moderate, and ginger's backing comes from a systematic review of nausea and vomiting. That review looked at nausea in general rather than hangovers specifically, and detailed hangover results for the others are thin, so the picture is still early.
Sources: PMID 10793599
- Supplements studied
- 1
- Graded outcomes
- 2
- Trials
- 1
- People studied
- 10
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Testosterone Mixed effect | 5 studies | 10 people | ||||
Studies that measured testosterone
| ||||||
| Estrogen No effect on estrogen during hangover | NoneNo effect | 10 people | ||||
Key findings
- Testosterone
- Estrogen
The Hangover Relief and Prevention protocol
2 primary supplements · 7 supporting supplements
- Dihydromyricetin (DHM)300–600 mg before or while drinking; 300 mg before bed
- ElectrolytesElectrolyte drink (sodium, potassium, magnesium) before bed and morning after
Studies cited
9 studies from PubMed
- Sex hormones and adrenocortical steroids in men acutely intoxicated with ethanol
- Effects of acute alcohol intake on pituitary-gonadal hormones in normal human males
- Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: a diet-controlled intervention study
- The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol
- Acute effect of alcohol on androgens in premenopausal women
- Acute ethanol administration enhances plasma testosterone levels following gonadotropin stimulation in men
- Testosterone increases in men after a low dose of alcohol
- Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise
- The effects of acute alcohol consumption on recovery from a simulated rugby match