Condition
Discirculatory Encephalopathy (DE)
Discirculatory encephalopathy is a long-term condition in which reduced blood flow damages the small vessels supplying the brain, leading to gradual memory problems and slower thinking; it is closely related to what Western medicine calls vascular cognitive impairment. Among supplements, vinpocetine has the most directly relevant finding, as cognitive symptoms improved in one small study. That study included only 20 people, so the evidence is limited, and larger trials in this exact condition are still needed.
Sources: PMID 21183904
- Supplements studied
- 1
- Graded outcomes
- 2
- Trials
- 1
- People studied
- 20
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cognitive Decline Improvement in cognitive symptoms | Improves (the measure goes down) | Small effect | 1 study | 20 people | ||
Studies that measured cognitive decline | ||||||
| Subjective Well-Being Small Improvement | Improves (the measure goes up) | Small effect | 1 study | 20 people | ||
Studies that measured subjective well-being | ||||||
Key findings
- Cognitive DeclineImproves (the measure goes down)
- Subjective Well-BeingImproves (the measure goes up)
The Discirculatory Encephalopathy (Chronic Cerebrovascular Insufficiency) protocol
2 primary supplements · 6 supporting supplements
- Ginkgo Biloba120–240 mg standardized extract (24% flavone glycosides, 6% terpene lactones) daily
- Citicoline (CDP-Choline)500–2,000 mg daily
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Discirculatory Encephalopathy (DE). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
3 studies from PubMed
- [Efficacy of cavinton in the treatment of patients with chronic blood flow insufficiency. Russian multicenter clinical-epidemiological program "CALIPSO"]
- Psychopharmacological effects of vinpocetine in normal healthy volunteers
- [Efficacy of vinpotropile in the therapy of initial signs of cerebrovascular pathology]