Dr. Grey AI

Spermidine

Spermidine is a polyamine that induces autophagy by inhibiting EP300 acetyltransferase. Epidemiological studies link higher dietary intake to 24% reduced mortality and lower cardiovascular/cognitive disease risk. RCTs show cognitive benefits in elderly. Major ongoing trial (POLYCAD) testing cardiovascular effects. One of the more promising longevity compounds with actual human data. Found in wheat germ, aged cheese, mushrooms, soybeans. Levels decline with age.

Quick Answer

What it is

Spermidine is a polyamine that induces autophagy by inhibiting EP300 acetyltransferase. Epidemiological studies link higher dietary intake to 24% reduced mortality and lower cardiovascular/cognitive disease risk.

Key findings

  • Grade C: Memory Performance (Cognitive Function)
  • Grade C: All-Cause Mortality
  • Grade C: Dementia Risk (Cognitive Function)

Safety

  • Epidemiological studies link higher dietary intake to 24% reduced mortality and lower cardiovascular/cognitive disease risk.
  • 26% lower dementia risk with higher dietary intake (epidemiological)
ℹ️ Quick Facts: Spermidine

Quick Facts: Spermidine

  • Best Evidence:Grade C
  • Conditions Studied:2
  • Research Outcomes:5
  • Key Effect:Cardiovascular Health
Outcomes by grade:
A0
B0
C4
D1
2 conditions · 5 outcomes

Detailed Outcomes

|
C
Memory Performance
Improved memory performance especially in those with mild cognitive impairment
2 studies
moderate↑Improves
C
Dementia Risk
26% lower dementia risk with higher dietary intake (epidemiological)
2 studies
moderate↓Improves
C
All-Cause Mortality
24% lower mortality with higher dietary spermidine intake (epidemiological)
2 studies
moderate↓Improves
C
Cardiovascular Mortality
Reduced cardiovascular mortality with higher dietary intake (epidemiological)
2 studies
moderate↓Improves
D
Blood Pressure
Trend toward reduced blood pressure in phase I safety trial
1 study
small↓Improves

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