Supplement
Spermidine is a compound found in foods like wheat germ, aged cheese and soybeans, and cells use it to support growth and to switch on their internal cleanup process. In population studies, people whose diets contained more of it had 24% lower mortality and 26% lower dementia risk. The evidence is limited, though: those studies only observed eating habits, and the small memory and blood pressure trials were early.
- Updated
- How we grade
- Best evidence
- Grade C
- Conditions studied
- 3
- Outcomes
- 5
- Graded outcomes
- 0041
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Memory Performance Improved memory performance especially in those with mild cognitive impairment | Improves (the measure goes up) | Moderate effect | 85 people | |||
| Dementia Risk 26% lower dementia risk with higher dietary intake (epidemiological) | Improves (the measure goes down) | Moderate effect | 800 people |
Longevity
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| All-Cause Mortality 24% lower mortality with higher dietary spermidine intake (epidemiological) | Improves (the measure goes down) | Moderate effect | 829 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cardiovascular Mortality Reduced cardiovascular mortality with higher dietary intake (epidemiological) | Improves (the measure goes down) | Moderate effect | 800 people | |||
| Blood Pressure Trend toward reduced blood pressure in phase I safety trial | Improves (the measure goes down) | Small effect | 30 people |
Key findings
- Memory PerformanceImproves (the measure goes up)
- All-Cause MortalityImproves (the measure goes down)
- Dementia RiskImproves (the measure goes down)
Safety notes in the studies
- 26% lower dementia risk with higher dietary intake (epidemiological)
Shop Spermidine
Third-party tested Spermidine products. The evidence above is limited, so read it before you buy.
- Grade C
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