Supplement
Punicalagins are large antioxidant compounds found in pomegranate peel and juice, which gut bacteria break down into smaller molecules the body can absorb. People mostly look at them for prostate cancer, but the evidence is limited: in one small study of 46 people, nitric oxide went up, while estrogen showed no clear difference. That is a very thin base, so these findings say little about whether punicalagins change anything that matters for prostate health.
- Updated
- How we grade
- 2 studies cited
- Best evidence
- Grade C
- Conditions studied
- 1
- Outcomes
- 6
- Graded outcomes
- 0011
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Nitric Oxide Small Increase | Improves (the measure goes up) | Small effect | 46 people | |||
| Estrogen No effect | NoneNo effect | 46 people | ||||
| Prostate-Specific Antigen | Improves (the measure goes up) | 2 studies | 138 people | |||
Studies that measured prostate-specific antigen | ||||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 46 people | ||||
| Prostate Cancer Risk | Improves (the measure goes down) | 138 people | ||||
| Testosterone | Improves (the measure goes up) | 46 people | ||||
Key findings
- Nitric OxideImproves (the measure goes up)
- Estrogen
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Third-party tested Punicalagins products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
2 studies from PubMed